Sodium Nasal Spray

Each milliliter of NASALCROM nasal spray contains 40 mg of cromolyn sodium in purified water with 0.01% benzalkonium chloride to preserve and 0.01% EDTA (ede- 

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Cromolyn sodium (Nasalcrom), a mast cell stabilizer, is available as a nonprescription nasal spray for symptomatic prevention and treatment of allergic rhinitis. 

Rynacrom containing sodium cromoglicate is available as a nasal spray used in allergic rhinitis. 

Sodium cromoglycate (CEIROMOTOP) 2 mg by aerosol TDS-QID, 2% nasal spray (FINTAL)... 

In this chapter, analysis of the excipient in Nasonex (mometasone naral spray) is used as a typical example to demonstrate how to select a proper analytical method. Nasonex Nasal Spray contains Mometasone Furoate, microcrystalline cellulose, and carboxymethylcellulose sodium NF, citric acid USP, sodium citrate USP, benzalkonium chloride solution NF, glycerin USP, polysorbate 80 NF, phenylethyl alcohol USP, and water USP. 

Each Imitrex Nasal Spray contains 5 or 20 mg of sumatriptan in a 100-pL unit-dose aqueous buffered solution containing monobasic potassium phosphate, anhydrous dibasic sodium phosphate, sulfuric acid, sodium hydroxide,... 

An 11-year-old girl was given desmopressin 10 micrograms by nasal spray per nostril for nocturnal enuresis (46). On the second night she took 3 puffs and at 3 a.m. awoke with a tonic-clonic fit. Her serum sodium concentration was 115 mmol/1. 

Selegiline hydrochloride Semduramycin sodium Serenda repcus, serenovarepens Sertraline hydrochloride Sevoflurene inhalation Sibutramine hydrochloride Sildenafil citrate Silymarin Simvastatin Sodium enoxaparin Sodium picosulfate Solution/nasal spray/injection... 

For allergic rhinitis and other allergic or inflammatory nasal conditions, a nasal spray containing dexamethasone isonicotinate is available the acetate, phosphate, sodium phosphate and sodium metasulfobenzoate have also been used. 

Brown HM, Engler C, English JR. A comparative trial of flunisolide and sodium cromoglycate nasal sprays in the treatment of seasonal allergic rhinitis. Clin Allergy 1981 ll(2) 169-73. 

Sodium cromoglicate eye drops and nasal spray may be helpful, as cumulative experience suggests that it has no effect on fetal development. However, as the patient is already under medical supervision, she should be referred back to her general practitioner or obstetrician to prescribe them. To help with the nasal congestion, you could suggest that the patient tries steam inhalations, using menthol or other suitable inhalants. 

Most corticosteroids nasal sprays (licensed preparations) are suspensions in which croscarmellose sodium is used as viscosity enhancer. The inhalation liquids for nebulisation with the same type of active substances however only contain polysorbate and sorbitan laureate to stabilise the suspension. For atomisation in jet nebulisers, the liquid should not be too viscous, in order to prevent clogging of the nebuliser. 

Pontiroli, A. E., Alberetto, M., Pajetta, E., Calderara, A., and Pozza, G., 1987, Human insulin plus sodium glycocholate in a nasal spray formulation Improved bioavailability and effectiveness in normal subjects. Diabetes Metab. 13 441-443. 

Schata, M., Jorde, W., and Richarz-Barthauer, U., 1991, Levocabastine nasal spray better than sodium cromoglycate and placebo in the topical treatment of seasonal allergic rhinitis, J. Allergy Clin. Immunol. 87 873-878. 

Sodium chloride 0.9% is safe and effective in relieving rhinorrhoea. It is safer to use in children than topical nasal decongestants (xylometazoline), which are to be avoided in children under 6 years as the latter are more likely are cause side-effects (such as effects on sleep or hallucinations). Budesonide spray is used for allergic conditions and is not normally used in paediatric patients. Benzydamine spray is a throat spray intended to relieve pain in the throat. Mupirocin is indicated for staphylococcal infections. 

Cromolyn Sodium, USP. Cromolyn stxlium. dlsodium 1.3 - bis (2 -carboxychnimon - 5 - yloxy) -2-hydroxy propane (Intal). is a hygroscopic, white, hydrated crystalline powder that is soluble in water (1 10). It i.s tasteless at first but leaves a very slightly biller aftertaste. The pK of cromolyn is 2.0. It is available as a solution for a nebuliz.cr. an aerosol spray, a nasal solution, an ophthalmic solution, and an oral concentrate. 

Cromolyn sodium (inhalation 20 mg/2 mL), Intal in capsules (20 mg for inhalation only), solution (20 mg per amp for nebulizer only), and aerosol spray (delivers 800 meg), Nasalcrom (nasal solution in 40 mg/mL), and Gastrocom (100 mg capsule for oral administration) are used for prophylactic management of severe bronchial asthma. As an antiasthmatic, antiallergic, and mast cell stabilizer, cromolyn has no bronchodilating, antiinflammatory, anticholinergic, or vas-oconstricting properties. 

Oven cleaners also contain strong bases such as sodium hydroxide. Many oven cleaners use aerosol sprays to distribute the cleaner on the inner surface of the oven. Care must be taken not to breathe air containing these aerosols because strong bases are quite corrosive to nasal tissue, bronchial tubes, and lungs. 

Aqueous nasal drops as well as sprays are suitable for self administration. Viscous solutions are best avoided, as they make less contact with the nasal mucosa. To clear a congested nose the patient can also sniff a salt solution (half a teaspoon of salt in a glass of lukewarm water) four to six times a day. The benefit of the addition of sodium hydrogen carbonate for a so-called alkaline nasal wash has not been demonstrated [2]. 

Nose drops and sprays that are not iso-osmotic have a negative influence on the ciliary epithelium. Hypo-osmotic solutions however are more ciliotoxic than hyper-osmotic ones [32]. Again the requirements should be more strict than for eye drops, because the diluting effect of the nasal liquid is much smaller than that of tears. Nasal drops are made iso-osmotic with sodium chloride, or in case of incompatibilities with glucose or mannitol. More information about osmotic pressure and tonicity, and the calculatimi of the osmotic value of solutions, is given in Sect. 18.5. 

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