Dexamethasone isonicotinate

C22H29FO5 50-02-2) see Dexamethasone lert-butylacetate Dexamethasone 21-isonicotinate Dexamethasone 21 -linolate Dexamethasone phosphate Dexamethasone pivalate dexamphetamine... 

Dexamethasone isonicotinate spray has been suggested as immediate treatment but its use may be as hazardous as the condition being treated. Beclomethasone dipropionate would be less dangerous but its effectiveness in treating this type of situation has not been tested. If it did not work, the victim might die before effective treatment was instituted. 

For allergic rhinitis and other allergic or inflammatory nasal conditions, a nasal spray containing dexamethasone isonicotinate is available the acetate, phosphate, sodium phosphate and sodium metasulfobenzoate have also been used. 

Dexamethasone Isonicotinate 539.5 Cephaeline Hydrochloride 608.5 Ambenonium Chloride... 

Brand P. Effect of a Local Inhalation Dexamethasone Isonicotinate Therapy on Toxic Pulmonary Edemas Caused by Phosgene Poisoning. Wurzburg, Germany University of Wurzburg 1971. Dissertation. 

No difference in systemic side effects was observed between beclomethasone dipropionate and betamethasone valerate (14 ). Dexamethasone isonicotinate may, however, produce less clinical response and exert a relatively greater suppressive effect on plasma cortisol than beclomethasone dipropionate (52 ). Further studies are needed to clarify possible differences between activity and side effects of different aerosol preparations. 

Dexamethasone (Merck) 1957 21 = acetate, palmitate, phosphate pivalate, isonicotinate,... 

Condensation of isoniazid (isonicotinic acid hydrazide) with any a" -3-ketosteroid in acidic medium affords a yellow color conjugate, allowing the determination of 10-40 pg of the steroid [73]. The reagent is prepared by dissolving 0.8 g of isoniazid in 100 mL of methanol containing 1 mL of concentrated HCl, and then 12.5 mL of this solution is further diluted to 100 mL with methanol. To a 2 mL methanolic sample solution of the 3-ketosteroid is added 2 mL of the reagent. The mixture is allowed to stand at room temperature for an hour, and then the absorbance of the resulting colored solution is measured at 380 nm. In a 1 cm spectrophotometer cell, an absorbance of 0.3 will be produced by 42 pg of cortisone, 34 pg of prednisolone, 29 pg of prednisone, or 32.5 pg of dexamethasone [72]. 

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