Sertraline hydrochloride

Administration of suspension - Shake suspension well before using. SERTRALINE HYDROCHLORIDE ... 

Davies, T.S. and Kluwe W.M. (1998) Preclinical toxicological evaluation of sertraline hydrochloride. Drug Chem Toxicol 21 521-537. 

Selective serotonin reuptake inhibitors fluoxetine hydrochloride fluvoxamine maleate paroxetine hydrochloride sertraline hydrochloride... 

Sertraline hydrochloride is a selective serotonin reuptake inhibitor for oral administration. It is chemically unrelated to other selective serotonin reuptake inhibitors or tricyclic, tetracyclic, or other available antidepressant agents. It is supplied in a multidose 60-mL bottle. Each milliliter of... 

USAN Sertraline Hydrochloride Trade Name Zoloft ... 

The most widely known SSRIs are fluoxetine hydrochloride (4, Prozac , Lilly), sertraline hydrochloride (5, Zoloft , Pfizer) and paroxetine hydrochloride (6, Paxil , GSK). Fluoxetine (4, Prozac ) was the first SSRl approved and effected a revolutionary change in the treatment of depression. In 2000, it was the most widely prescribed antidepressant drug in the United States with worldwide sales of 2.58B. Sertraline (5, Zoloft ) has been available in the United States since 1992 and had worldwide sales of 2.14B in 2000. Compared to fluoxetine (4), it has a shorter duration of action and fewer CNS activating side-effects such as nervousness and anxiety. Paroxetine (6, Paxil ) generated worldwide sales of 2.35B in 2000 and has a relatively benign side-effect profile, which favors its use with elderly patients. 

Synthesis of fluoxetine hydrochloride 10.3 Synthesis of sertraline hydrochloride 10.4 Synthesis of paroxetine hydrochloride 10.5 References... 

The molecular ion in the electrospray mass spectrum of the Pfizer anti-depressant Lustral (sertraline hydrochloride), CiyHigNCb, contains the peaks shown in Figure 5.25. Explain the relative intensities of these peaks (given in brackets above each peak). 

Johnson BM, Chang P-TL. Sertraline hydrochloride. In Brittain HG, ed. Analytical Profiles of Drug Substances and Excipients. Vol. 24. New York Academic Press, 1996 484. 

Imines readily hydrolyze under basic or acidic conditions. Figure 52 shows the acid-catalyzed hydrolysis of imines. When developing methods to detect imines, it is often necessary to use neutral pH conditions to optimize the stability of the imine. An example of imine formation and hydrolysis is found in the degradation chemistry of the API sertraline hydrochloride (Fig. 53) (86). 

Figure 53 The secondary amine of sertraline hydrochloride is oxidized to an imine and then hydrolyed to a ketone under acidic conditions.

Aryl halides are often susceptible to photochemical degradation. As described in Chapter 10 later in this book, cleavage of the C-X bond occurs with low quantum yield for aryl chlorides (132), higher quantum yields for aryl bromides and iodides (133), and high quantum yields for some aryl fluorides (e.g., fluoroquinolones) (134). Aryl chlorides are photolabile to homolytic and/or heterolytic dechlorination (43). For sertraline hydrochloride, decomposition of the aryl dichloride moiety occurs in solution when exposed to light (ultraviolet and fluorescent conditions). As shown in the following proposed mechanism, the major photochemical decomposition products include mono-chloro- and des-chloro-sertraline via homolytic cleavage (Fig. 91) (86). 

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