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Rhinitis, allergic

The mucosal inflammatory changes seen in allergic rhinitis are very similar to those described for asthma above. [Pg.67]

4 Do Mast Cells Initiate Late Phase Inflammatory Reactions  [Pg.68]

The relevance of mast cell cytokines to the inflammatory response during parasite infection however is less clear. Nogami etal. (1990) demonstrated that in contrast [Pg.68]

Taken together, these findings indicate that mast ceU-derived TNFa, and probably other mast ceU-derived cytokines such as IL-4 and IL-5, are likely to be involved in human LPRs, and therefore by inference, chronic human aUetgic inflammation. Many resident and recruited inflammatory ceUs have the potential to secrete further cytokines in response to mast cell cytokine release. This sugg ts that the response to release of mast cell cytokines may extend fiir beyond the changes mediated directly by mast cell cytokines themselves, and has led to the concept of the mast cell-leucocyte cytokine cascade (Galli, 1993). [Pg.68]

The lack of a specific marker for basophils has hampered studying them in allergic diseases, and their relative [Pg.68]

X = Cl chlorpheniramine (Chlor-Trimeton), A.5 X = Br brompheniramine (Dimetapp), A.6 KJ tripolidine A.7 [Pg.358]

FIGURE A.3 Second-generation antihistamines and later drugs [Pg.359]

Ketotifen Mequitazine Nedocromil sodium Oxatomide Mast cell stabihzer [Pg.55]

Avoiding the offending allergens is the best preventative treatment. The aforementioned medications are symptom-  [Pg.55]

FIGURE 18 Allopurinol reduces the synthesis of uric acid by inhibiting the activity of xanthine oxidase. Not only is it used in treating the hyperuricemia associated with gout, but also in the secondary hyperuricemia associated with the use of antineoplastic agents. Allopurinol may interfere with the metabolism of antineoplastic agents. Allopurinol may interfere with the metabolism of antineoplastic agents such as azathioprine and 6-mercaptopurine. [Pg.55]

Gout is a hyperuricemic state ( 6 mg/dL) that is effectively diagnosed through the detection of monosodium urate crystals in the synovial fluid of the involved joint. [Pg.55]

Conditions causing hyperuricemia include the excessive synthesis of uric acid, the excessive synthesis of purine— precursor to uric acid—a high dietary intake of purine (shellfish, organ meat, anchovies, and wild game), diminished renal excretion of uric acid, and tissue destruction following injury or therapeutic irradiation. [Pg.56]


Allergic Seasonal or Perennial Rhinoconjunctivitis. Histamine can cause all pathologic features of allergic rhinitis (35—37), with the exception of late-phase inflammatory reactions. Pmritus is caused by stimulation of receptors on sensory nerve endings prostaglandins (qv) may also contribute. Sneering, like pmritus, is an H -mediated neural reflex and can also be mediated by eicosanoids. Mucosal edema, which manifests as nasal... [Pg.141]

Allergic Rhinitis inflammation of the mucous membranes in the nose that is caused by an allergic reaction. [Pg.517]

Ramatroban is a PG receptor antagonist in use for the treatment of allergic rhinitis in Japan. This compound was initially identified as a TP receptor antagonist, although more recently it has been determined that it is also antagonizes the CRTH2 (DP2) receptor. [Pg.1004]

Ragweed SC/Pollinex Quatro Agonist Allergic rhinitis (Ragweed) Phase II clinical trials... [Pg.1211]

Decongestants are used to treat the congestion associated with rhinitis, hay fever, allergic rhinitis, sinusitis, and the common cold. In addition, they are used in adjunctive therapy of middle ear infections to decrease congestion around the eustachian tube Nasal inhalers may relieve ear block and pressure pain during air travel. Many can be administered orally as well as topically, but topical application is more effective than the oral route. [Pg.329]

The corticosteroids are used in the management and prophylactic treatment of the inflammation associated with chronic asthma or allergic rhinitis. [Pg.338]

Intal, Nasalcrom Prophylaxis of severe bronchial asthma prevention of exercise-induced asthma (BA) Nasal preparations prevention and treatment of allergic rhinitis Dizziness, headache, nausea, dry and irritated throat, rash, joint swelling and pain... [Pg.340]

MH, Townley RG. Mokhtarani M. Seyfert-Margohs V, Asare A. Bateman K. Deniz Y Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis. J Allergy Clin Immunol 2006 117 134-140. [Pg.44]

Allergic rhinitis Nasal congestion model Decreases congestion (together with Hi antagonist) [59]... [Pg.183]

Mother had asthma as a child, but "outgrew" it and has had no problems with it since she was 12 or 13 years old both her mother and father have allergic rhinitis... [Pg.224]

Budesonide (Rhinocort) 32 meg spray, 1-4 sprays in each nostril daily Preferred corticosteroid for allergic rhinitis. [Pg.728]

Cetirizine (Zyrtec) 10 mg orally daily Second-line agent for allergic rhinitis during second and third trimesters only. [Pg.728]

Hypertension diagnosed 5 years ago, currently controlled Seasonal allergic rhinitis... [Pg.827]


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