Selegiline hydrochloride

Pharmacology Selegiline hydrochloride is a levorotatory acetylenic derivative of phenethylamine. Although the mechanism of action is not fully understood, inhibition of monoamine oxidase (MAO) type B activity is of primary importance and selegiline... 

Table 1 (48a,b) shows the 24 hr results of the test described above on phenylbutazone. Copper degraded phenylbutazone both as a salt and as acetyl acetonate. Iron was less aggressive, and the free salt was stronger than the complex. The degradation products were 4-hydroxy- and 4-hydroperoxy-phenylbutazone, the known oxidation impurities. The susceptibility of phenylbutazone to metal oxidation can be attributed to activation of the hydrogen on C-4 by the adjacent carbonyls. Selegiline hydrochloride, a stable compound, was not oxidized under the same conditions. This confirms the discriminating power of the experimental conditions. 

Selegiline hydrochloride Semduramycin sodium Serenda repcus, serenovarepens Sertraline hydrochloride Sevoflurene inhalation Sibutramine hydrochloride Sildenafil citrate Silymarin Simvastatin Sodium enoxaparin Sodium picosulfate Solution/nasal spray/injection... 

Selegiline hydrochloride (Eldepryi L-de-prenyl i -(-)-N,2-dimethyl-N-2-propynyl-phenethylamine, 37 Fig. 12.8), at low doses (a 10 mg/day), is a selective inhibitor of mainly nonneuronal MAO-B, which oxidizes MPTP... 

Eldepryl (Selegiline hydrochloride). Orion Pharma (UK) Ltd. UK Summary of product characteristics, July 2006. 

Selegiline hydrochloride tablets USP. Endo Generic Products. US Prescribing information, November 2001. 

Selegiline [(/ )(-)-W,a-dimethyl-W-(2-propynyl)benzeneethanamine, Elde-pryl. Deprenyl, 1] is a phenethylamine derivative which is pharmacologically active in the levo form. It is indicated as adjuvant treatment with levo-dopa in Parkinson s disease, and is supplied as a 5 mg tablet of selegiline hydrochloride. It belongs to the class of type B inhibitors of monoamine oxidase (MAOI-B). At high doses (>40 mg/day in man), selegiline loses its MAOI-B specificity and also inhibits MAO-A. 

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