Sibutramine hydrochloride

C3HfiBr2 109-64-8) see Brinzolamide Carpipramine Dibrornpropamidine Ethoheptazine Pentoxifylline Sibutramine hydrochloride 23-dibromo-1 -propanol... 

C 4H 4N 201030-97-9) see Imiquimod (2-methylpropyl)magnesium bromide (C4H9BrMg 926-62-5) see Repaglinide Sibutramine hydrochloride... 

Gillman, PK (1999) The serotonin syndrome and its treatment. J. Psychopharmacol. 13 100-109. Heal, DJ, Cheetham, SC, Prow, MR, Martin, KF and Buckett, WR (1998) A comparison of the effects on central 5-HT function of sibutramine hydrochloride and other weight-modifying drugs. Brit. J. Pharmacol. 125 301-308. 

Heal, DJ, Butyler, SA, Hurst, EM and Buckett, WR (1989) Antidepressant treatments, including sibutramine hydrochloride and electroconvulsive shock, decrease betal- but not beta2-adrenoceptors in rat cortex. J. Neurochem. 53 1019-1025. 

Selegiline hydrochloride Semduramycin sodium Serenda repcus, serenovarepens Sertraline hydrochloride Sevoflurene inhalation Sibutramine hydrochloride Sildenafil citrate Silymarin Simvastatin Sodium enoxaparin Sodium picosulfate Solution/nasal spray/injection... 

Sibutramine hydrochloride is an anorexiant that inhibits reuptake of norepinephrine, serotonin and dopamine. It may stimulate the satiety center in brain, causing appetite suppression. It is indicated as an adjunct to a reduced calorie diet for the management of obesity, including weight loss and maintenance of weight loss. Recommended for patients with an initial body mass index greater than 30 kg/m2 or greater than 27 kg/m in the presence of other risk factors (e.g., hypertension, diabetes, dyslipidemia). 

Reductil (Sibutramine hydrochloride monohydrate). Abbott Laboratories Ltd. UK Summary of product characteristics, November 2005. 

Twelve obese patients were given sibutramine hydrochloride monohydrate 20 mg daily for 14 days, with ketoconazole 200 mg twice daily for the last 7 days. Ketoconazole caused moderate increases in the serum levels of sibutramine and its two metabolites (AUC and maximum serum level increases of 58% and 36%, respectively, for metabolites Ml, and 20% and 19%, respectively, for M2, probably through inhibition of the cytochrome P450 isoenzyme CYP3A4). Small increases in heart rates were seen (2.5 bpm at 4 hours and 1.4 bpm at 8 hours), while ECO parameters were unchanged. Sibutramine alone can cause an increase in heart rate, and a rate increase of 10 bpm is an indication to withdraw the drug. There-... 

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