Salivary epithelium

Nogawa H, Takahashi Y (1991) Substitution for mesenchyme by basement-membrane-like substratum and epidermal growth factor in inducing branching morphogenesis of mouse salivary epithelium. Development 112 855-861. 

The mouth is the region from the lips to the pharynx. The first step in the digestive process is chewing, or mastication, which is an initial mechanical breakdown of the food that facilitates its movement to the stomach. The mouth is lined with stratified squamous epithelium that provides extra protection from injury by coarse food materials. Three pairs of salivary glands secrete saliva into the oral cavity ... 

Water-soluble methylglyoxal adenine derivative 11 has recently been reported as a potentiator of wild-type and F508del-CFTR mutations in several cell lines [55]. Ex vivo addition of 11 to cftr mice colonic epithelium induced a dose-dependent elevation of chloride secretion with a measured EC50 of 175 + 1.1 pM. In vivo, in cftr+/ mice, addition of 11 in the presence of isoprenaline induced a dose-dependent salivary secretion with an EC50 of 7.1 + 1.1 pM whereas no effect of isoprenaline and 11 was observed on the salivary secretion of cftr mice. 

WiGLEY, C.B. (1979). "Hansformation in vitro of adult mouse salivary gland epithelium a system for studies on mechanisms of initiation and promotion, page 3 in Neoplastic Thinsformation in Differentiated Epithelial Cell Systems In Vitro, Franks, L.M. and Wigley, C.B., Eds. (Academic Press, London). 

AQP-5 Fluid secretion in salivary glands, lachrymal glands, and alveolar epithelium of lung... 

The watery component of saliva moistens and lubricates the masticatory process. Salivary mucus helps to bind the food bolus ready for swallowing. The surface coating of mucus also serves to protect the epithelium from potentially harmful substances. Enzymes present in the saliva initiate the digestive process. 

Local factors, systemic factors, or a combination of both can cause halitosis. It is estimated that 80%i of all mouth odors are caused by local factors within the oral cavity, and these odors are most often associated with caries, gingivitis, and periodontitis. Oral malodors occur because of the action of various microorganisms on proteinaceous substances, such as, exfoliated oral epithelium, salivary proteins, food debris, and blood.t ]... 

Analysis of in vivo-formed pellicle by a combination of electrophoretic separation and MALDI-TOF showed the presence of intact histatin 1, cystatin SN, statherin, lysozyme, albumin and amylase [15, 39], In addition, intact cytokeratins 13 and 15 and calgranulin B were identified as components of the salivary pellicle layer for the first time using MALDI-TOF mass spectrometry [15]. Calgranulin B has been shown to be a component of saliva and gingival crevicular fluid [15]. The identification of cytokeratins in the salivary pellicle layer points to the oral epithelium as one of the sources of proteins adsorbed on the tooth surface. 

As noted earher (Sect. 12.1.3), the reduced enamel epithelium is replaced with adherent salivary proteins, mostly amylase and acidic proline-rich proteins. The acidic PRPs are at about a three times greater concentration than in secreted saliva. The acidic domain of these proteins especially has a high affinity for hydroxyapatite. Once bound to pelhcle, the N-terminus of acidic-PRPs forms an attachment site for the major classes of commensal bacteria (viridans streptococci and Actinomyces spp.) that occupy the mucosal surfaces and saliva of a healthy oral cavity. Some streptococci grow by themselves in dental biofilms, but many others grow better if certain Actinomyces spp. are also present. 

This tumor is similar to its counterpart in salivary glands in both morphology and immunophenotype and may arise in the cervix or vulvovaginal soft tissue. It is a dual-cell population tumor growing in cribriform, tubular, and/or solid patterns. The major cell type is a basaloid polygonal cell with modified myoepithelial features, and it is positive for p63 and smooth muscle actin. The minor cell type is an epithelial cell forming tiny ductules that may be inconspicuous. These cells express keratin and CD 117. Distinction from basaloid squamous carcinoma is based on the distinct morphology of adenoid cystic carcinoma because overlap exists in immunostains p63 is diffusely expressed in basaloid squamous carcinoma, as opposed to adenoid cystic carcinoma, in which p63 is confined to basaloid cells and not epithelium of the ductules CDl 17 can be expressed at low levels in basaloid squamous carcinoma. ... 

Breast ductal epithelium, epithelium of lung, GIT and hepatobiliary, kidney, salivary and sweet glands... 

Cytokeratin 7 (CK7) Adenocarcinoma of lung, GIT, pancreas, biliary tract, breast, endometrium, transitional cell carcinoma, serous ovarian tumors Merkel cell carcinoma, cloacogenic carcinoma Epithelium of GIT, salivary glands, biliary tract, pancreas, lung, female genital tract, renal collecting ducts transitional epithelium, mesothelial cells, thyroid follicle cells... 

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