Epithelial cell differentiation

Gorodeski GI, Eckert RL, Utian WH, Sheean L, and Rorke EA [1990] Cultured human ectocervical epithelial cell differentiation is regulated by the combined direct actions of sex steroids, glucocorticoids and retinoids. J Clin Endocrinol Metab 70 1624-1630... 

Agarwal C, Rorke EA, Irwin JC, and Eckert RL [1991] Immortalization by human papillomavirus type 16 alters retinoid regulation of human ectocervical epithelial cell differentiation. Cancer Res 51 3982-3989... 

Vaughan, M. B., R. D. Ramirez, W. E. Wright, J. D. Minna, and J. W. Shay. 2006. A three-dimensional model of differentiation of immortalized human bronchial epithelial cells. Differentiation 74(4) 141-8. 

Because vitamin A regulates epithelial cell differentiation and proliferation, there has been considerable interest in the apparent ability of retinol and related compounds to interfere with carcinogenesis. Vitamin A deficiency in humans enhances susceptibility to carcinogenesis. 

Abbott BD, Bimbaum LS. 1989b. TCDD alters medial epithelial cell differentiation during palatogenesis. Toxicol Appl Pharmacol 99 276-286. 

Abbott BD, Diliberto JJ, Bimbaum LS. 1989. 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters embryonic palatal medial epithelial cell differentiation in vitro. Toxicol Appl Pharmacol 100 119-131. 

Although rodent buccal mucosa is reported to consist of both keratinized and non-keratinized striated epithelia, no evidence for the latter was obtained in the present study. In all rodents examined, heavily keratinized striated epithelia were observed on the inner central cheek (see Figure 1 for rat). Mucosal sections exhibited characteristic epithelial cell differentiation with cells becoming progressively flatter and forming a granular layer with increasing distance from the basal cell layer. The outer... 

Halttunen T, Maki M. Serum immunoglobulin A from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation. Gastroenterology 1999 116 566-572. 

Abnormal nutrient delivery may also have an effect on lung growth and development. Subtle deficiencies of vitamin A can affect airway branching and lung epithelial cell differentiation [46]. There are additional effects of vitamin A depletion on surfactant protein production which in turn could affect airway host defence [47]. Collectively, these phenomena are viewed as key abnormalities in asthma. There is, therefore, a potential for aberrant nutrient delivery to have an impact not only on IgE sensitisation to allergen but also on airway development. Clearly further research is required in this area. 

Cardoso WV, Williams MC, Mitsialis SA, et al Retinoic acid induces changes in the pattern of airway branching and alters epithelial cell differentiation in the developing lung in vitro. Am J Respir Cell Mol Biol 1995 12 464-476. 

Tang DG, Bhatia B, Tang S, Schneider-Broussard R. 15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size). Prostaglandins Other Lipid Mediat. 82 (2007) 135-146. 

Park SM, Jung HC, Koak IS et al. Oxidant-induced cell death in renal epithelial cells Differential effects of inot nic and organic hydroperoxides. Pharmacol Toxicol 2003 92 43-50. 

Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, Thalmaim G, D Ambrosio G, Sarti M, Sessa F, Chiorino G, Catapano CV, Carbone GM. ESE3/EHF controls epithelial cell differentiation and its loss leads to nostate tumors with mesenchymal and stem-like features. Cancer Res. 2012 72 2889-900. 

Simon-Assmann, R, Turck, N., Sidhoum-Jenny, M., Gradwohl, G., and Kedinger, M. 2007. In vitro models of intestinal epithelial cell differentiation. Cell Biol Toxicol, 23 241-256. 

MANLEY N (2000) Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation. Seminars in Immunology, 12,421 28. 

A549-cells, a human airway epithelial carcinoma cell line with type II alveolar epithelial cell differentiation, dislodged before use with a 0.25 per cent trypsin solution, did not contain any detectable glutathione peroxidase (Rietjens et al. 1985). 

Hino K, Tsuchiya K, Fukao T, Riga K, Okamoto R, Kanai T, Watanabe M (2008) Inducible expression of microRNA-194 is regulated by HNF-1 alpha during intestinal epithelial cell differentiation. RNA 14(7) 1433-1442... 

Retinoic acid (Dl) is formed irreversibly from retinaldehyde (Futterman, 1962) and therefore is not a precursor for rhodopsin. Retinoic acid supports growth, promotes epithelial cell differentiation, and suppresses neoplastic development (e.g., Zile et al., 1979 Roberts and Frolik, 1979 Lotan, 1980). It occurs in the retina (Saari et al., 1982), but it is not known whether it has a speciflc retinal function. 

Wozniak, M.A., Desai, R., Solski, P.A., Der, C.J., and Keely, P.J. (2003) ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen... 

Corbeil D, Marzesco AM, Wilsch-Brauninger M, Huttner WB. The intriguing links between prominin-1 (CD133), cholesterol-based membrane microdomains, remodeling of apical plasma membrane protrusions, extracellular membrane particles, and (neuro)epithelial cell differentiation. FEES Lett. 2010 584(9) 1659-1664. 

Ogier-Denis, E. Blais, A. Houri, J.J. Voisin, T. Trugnan, G. Codogno, P. The emergence of a basolateral l-deoxymannojirimycin-sensitive mannose carrier is a function of intestinal epithelial cell differentiation. Evidence for a new inhibitory effect of 1-deoxymannojirimycin on facilitative mannose transport. J. Biol Chem. 1994, 269, 4285-4290. 

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