Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Merkel cell carcinoma

Soslow RA, Wallace M, Goris J, et al. MIC2 gene expression in cutaneous neuroendocrine carcinoma (Merkel cell carcinoma). Appl Immunohistochem. 1996 4 235-240. [Pg.130]

Heenan PJ, Cole JM, Spagnolo DV. Primary cutaneous neuroendocrine carcinoma (Merkel cell tumor) an adnexal epithelial neoplasm. Am Dermatopathol. 1990 12 7-16. [Pg.493]

Sometimes the distribution of keratin staining in a particular cell may aid in determining its origin. As mentioned before, Merkel cell and other neuroendocrine carcinomas characteristically have a perinuclear ball-like reactivity. [Pg.424]

Miettinen, M. (1995) Immunohistochemical marker for gastrointestinal, urothelial, and Merkel cell carcinoma. Mod. Pathol. 8, 384-388. [Pg.435]

Greenlee JE, Steffens JD, Clawson SA, Hill K, Dalmau J. Anti-Hu antibodies in Merkel cell carcinoma. Atm Neurol 2002 52(1) 111115. [Pg.174]

A second cancer is possible when treating a tnmor by mutagenicity or immunosnppression. There may be a link between the therapy given and the development of Merkel cell carcinoma (21). [Pg.3070]

A 54-year-old man with stage I folUcnlar Ijmphocytic lymphoma with cervical lymph nodes nnderwent splenectomy followed by chemotherapy with chlorambncil and had a partial response. Five months later, when he developed generalized lymphadenopathy and bone marrow involvement, he received fludarabine, cyclophosphamide, and ritnximab, with complete remission. Ten months later he developed a Merkel cell carcinoma involving the liver and lymph nodes. The disseminated tumor was chemoresistant and he died. His lymphoma remained in complete clinical remission throughout this time. [Pg.3070]

Small cell neuroendocrine (Merkel cell) carcinoma... [Pg.103]

Buresh CJ, Oliai BR, Miller RT. Reactivity with TdT in Merkel cell carcinoma A potential diagnostic pitfall. Am J Clin Pathol. 2008 129 894-898. [Pg.133]

Kontochristopoulos GJ, Stavroporrlos PG, Krasagakis K, et al. Differentiation between Merkel cell carcinoma and malignant melanoma an immrmohistochemical study. Dermatology. 2000 201 123-126. [Pg.203]

Battifora H, Silva EG. The use of antikeratin antibodies in the immunohistochemical distinction between neutoendoctine (Merkel cell) carcinoma of the skin, lymphoma, and oat cell cat-cinoma. Cancer. 1986 58 1040-1046. [Pg.204]

CK20 (+) colorectal, pancreas, mucinous ovarian, Merkel cell, and urothelial carcinomas. [Pg.217]

Chan JK, Suster S, Wenig BM, et al. Cytokeratin 20 immuno-reactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol. 1997 21 226-234. [Pg.247]

Cheuk W, Kwan MY, Suster S, et al. Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas. Arch Pathol Lab Med. 2001 125(2) 228-231. [Pg.287]

In their study of thyroid and pulmonary carcinomas, Kaufmann and DieteP" demonstrated reactivity for surfactant protein A in 3 of 7 thyroid carcinomas in a focal pattern. Byrd-Gloster and coworkers reported that TTF-1 is useful in the distinction of pulmonary small cell carcinomas from Merkel cell carcinomas. In their study, 97% of small cell bronchogenic carcinomas were TTF-1 positive, whereas none of 21 Merkel cell tumors exhibited positivity. However, TTF-1 has been reported in some nonpulmonary small cell carcinomas including those arising in the prostate, urinary bladder, and uterine cervix (see Table 10.6). ... [Pg.300]

FIGURE 10.51 Merkel cell carcinoma. Immunoperoxidase stain for cytokeratin 20 shows a dotlike pattern of staining. [Pg.327]

Merkel cell (NE) carcinoma of the skin is an uncommon entity that was first described as trabecular carcinoma. These tumors are uniformly positive for broad-spectrum cytokeratins and stain positively for CK20 in 97% of cases, with a dotlike pattern of reactivity (Fig. 10.51, Table 10.5). °F344 xhis high frequency of CK20 immu-noreactivity has been confirmed in many other stud-... [Pg.327]

Some studies have shown c-kit positivity in up to 95% of cases.Pulmonary small cell carcinomas may also be positive for c-kit.Nuclear localization of E-cadherin immunoreactivity has been reported in Merkel cell carcinomas and may have diagnostic utility... [Pg.328]

An additional approach to the distinction of Merkel cell tumors from small cell pulmonary carcinomas involves the use of antibodies to the mammalian achaete-scute complex-like protein (MASH). Although more than 80% of small cell pulmonary carcinomas are MASH positive, only 1 of 30 Merkel cell carcinomas was positive for this marker. Merkel cell carcinomas also express the K homology domain containing protein (KOC), similar to other high-grade NE malignancies. [Pg.328]

Molecular alterations underlying the development and progression of Merkel cell carcinomas are poorly understood. Recently, Feng and coworkers reported the identification of a fifth human polyoma virus that was designated Merkel cell polyomavirus on the basis of its detection in Merkel cell carcinomas. A subsequent study by Kassem and colleagues analyzed 39 Merkel cell carcinomas and found the presence of Merkel cell polyomavirus DNA in 77% of cases. This study was limited in that the use of formalin-fixed paraffin tissues... [Pg.328]

C-kit positivity in these tumors has led to investigations of the efficacy of imatinib, a specific inhibitor of tyrosine kinases. This agent has been shown to decrease proliferation of Merkel cell carcinomas cells in... [Pg.328]

Byrd-Gloster AL, Khoor A, Glass LE, et al. Differential expression of thyroid transcription factor-I in small cell lung carcinoma and Merkel cell tumor. Hum Pathol. 2000 31 58-62. Agoff SN, Lamps LW, Philip AT, et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary NE tumors. Mod Pathol. 2000 13 238-242. [Pg.331]

Leech SN, Kolar AJO, Barrett PD, et al. Merkel cell carcinoma can be distinguished from metastatic small cell carcinoma using antibodies to cytokeratin 20 and thyroid transcription factor 1. ] Clin Pathol. 2001 54 727-729. [Pg.338]

Hanly AJ, Elgart GW, Jorda M, et al. Analysis of thyroid transcription factor-1 and cytokeratin 20 separates Merkel cell carcinoma from small cell carcinoma of lung. J Cutan Pathol. 2000 27 118-120. [Pg.338]

Jensen K, Kohler S, Rouse RV. Cytokeratin staining in Merkel cell carcinoma An immunohistochemical study of cytokera-tins 5/6, 7, 17, and 20. Appl Immunohistochem Mol Morph. 2000 8 310-315. [Pg.338]

Liu Y, Mangini J, Saad R, et al. Diagnostic value of microtubule-associated protein-2 in Merkel cell carcinoma. 2003 11 326-329. [Pg.338]

Sibley RK, Dahl D, Primary NE. (Merkel cell ) carcinoma of the skin. II An immunohistochemical study of 21 cases. Am J Surg Pathol. 1985 9 109-116. [Pg.338]

Dinh V, Eeun L, Elgart G, et al. Merkel cell carcinomas. Hema-tol Oncol Clin North Am. 2007 21(3) 527-544. [Pg.338]

See other pages where Merkel cell carcinoma is mentioned: [Pg.214]    [Pg.422]    [Pg.214]    [Pg.422]    [Pg.424]    [Pg.391]    [Pg.381]    [Pg.46]    [Pg.161]    [Pg.214]    [Pg.216]    [Pg.217]    [Pg.226]    [Pg.227]    [Pg.227]    [Pg.327]    [Pg.328]    [Pg.328]    [Pg.328]   
See also in sourсe #XX -- [ Pg.327 , Pg.375 ]



SEARCH



Carcinoma cells

Merkel cell carcinoma aloe-emodin effects

Merkel cells

© 2024 chempedia.info