Attachment sites

Acid (SNl-like) Condition R OH Nu attachs site that best... 

Fig. 1. The GP Ib-IX-V complex. The complex consists of seven transmembrane polypeptides denoted GP Iba (mol wt 145,000), GP IbP (mol wt 24,000), GPIX (mol wt 17,000) and GP V (mol wt 82,000), in a stoichiometry of 2 2 2 1. The hatched region represents the plasma membrane. The area above the hatched region represents the extracellular space that below represents the cytoplasm. The complex is a major attachment site between the plasma membrane and the cytoskeleton. Two molecules associated with the cytoplasmic domain are depicted a 14-3-3 dimer, which may mediate intracellular signaling, and actin-binding protein, which connects the complex to the cortical cytoskeleton and fixes its position and influences its function.

Picornaviruses construct their shells from 60 copies each of three different polypeptide chains. These 180 subunits are arranged within the shell in a manner very similar to the 180 identical subunits of bushy stunt virus. In some picornaviruses there are protrusions around the fivefold axes, which are surrounded by deep "canyons." In rhinoviruses, the canyons form the virus s attachment site for protein receptors on the surface of the host cells, and they are adjacent to cavities that bind antiviral drugs. 

Attachment site density effects in inorganic primer films... 

In addition to the beneficial effects of creating a textured surface, inorganic primers can provide a very high density of specific chemical attachment sites for... 

G() is related to the reversible work of adhesion obtained using contact angle measurements, but in general is greater than W. This is because once an interface is formed and the adhesive solidifies, strain energy is required to mechanically disrupt the interface. This strain energy arises because of the physical connection between the attachment sites between the adhesive and the substrate and the connectivity between this interface and the adhesive bulk. 

Masking of a site Association between two proteins can be disrupted by SUMOylation, if the SUMO attachment site of a target protein overlaps with the... 

Even though dynein, kinesin, and myosin serve similar ATPase-dependent chemomechanical functions and have structural similarities, they do not appear to be related to each other in molecular terms. Their similarity lies in the overall shape of the molecule, which is composed of a pair of globular heads that bind microtubules and a fan-shaped tail piece (not present in myosin) that is suspected to carry the attachment site for membranous vesicles and other cytoplasmic components transported by MT. The cytoplasmic and axonemal dyneins are similar in structure (Hirokawa et al., 1989 Holzbaur and Vallee, 1994). Current studies on mutant phenotypes are likely to lead to a better understanding of the cellular roles of molecular motor proteins and their mechanisms of action (Endow and Titus, 1992). 

The use of the phenyl phosphate group as both a solid support attachment site and a crucial binding element represents what has been referred to as a pharmacophore-linking strategy [26]. We explored a variety of phenyl phosphate tether functionalities to provide resins varying in substitution pattern and in chemical flexibility (Scheme 1 and Table 4) [22]. All phenyl phosphate resins were synthesized in batch quantities of 20 g or more. Resin synthesis began with the addition of either /mnethoxy-benzyl alcohol or benzyl alcohol to commercially available bis(diisopro-pylamino)chlorophosphine, followed by addition of the diversity phenol [(Ri)-OFl, DIAT (diisopropylamino tetrazole)]. Displacement of the... 

Nurse With respect to the astral microtubules emanating towards the cortex, which are shorter in the gyg-8 mutant, are the pulling forces a consequence of the microtubules in wild-type being attached to the cortex, or are they due to attachment sites in the cytoplasm and associated motors, which means that if you extend longer into the cortex you would have a bigger pulling force than if you are shorter ... 

Pittenauer, E. Quintela, J. C. Schmid, E. R. Allmaier, G. Paulus, G. de Pedro, M. A. Characterization of Braun s lipoprotein and determination of its attachment sites to peptidoglycan by 252-Cf-PD and MALDI time-of-flight mass spectrometry. /. Am. Soc. Mass Spectrom. 1995, 6, 892-905. 

In general, virus receptors carry out normal functions in the cell. For example, in bacteria some phage receptors are pili or flagella, others are cell-envelope components, and others are transport binding proteins. The receptor for influenza vims is a glycoprotein found on red blood cells and on cells of the mucous membrane of susceptible animals, whereas the receptor site of poliovirus is a lipoprotein. However, many animal and plant viruses do not have specific attachment sites at all and the vims enters passively as a result of phagocytosis or some other endocytotic process. 

Figure 5.26 Integration of lambda DNA into the host. Integration always occurs at a specific site on the host DNA, involving a specific attachment site (att) on the phage. Some of the host genes near the attachment site are given. A sitespecific enzyme (integrase) is involved, and specific pairing of the complementary ends results in integration of phage DNA.

It might also be expected that the aromatic portion of the PAH alkylating agent will tend to lie in the interior of the protein, as far as possible from the hydrophilic surface and its aqueous environment. Thus the result of alkylation can be extensive and can lead to a loss of any function, such as catalytic activity (if the protein is an enzyme) and/or loss of ability to recognize an attachment site or another macromolecule. 

Attachment sites for a molecule within a single molecule junction... 

Fig. 2.—Chemical structure of lipid A of the Escherichia coli Re mutant strain F515. The hydroxyl group at position 6 constitutes the attachment site of Kdo. The numbers in circles indicate the number of carbon atoms present in the fatty acyl chains. The 14 0(3-OH) residues possess the (Reconfiguration. The glycosylic phosphate group may be substituted by a phosphate group (see Table I) (46,65,69).

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