Feline leukemia virus

PMEA and its congeners are more effective in vivo than could be predicted from their in vitro potency. While less potent as an antiretrovirus agent than AZT in vitro, PMEA proved clearly superior to AZT when the two drugs were compared for their effectiveness in vivo, in mice infected with murine Moloney sarcoma virus [51,52]. PMEA was also shown to be effective against various other retrovirus infections, including Friend leukemia virus (FLV), Rauscher leukemia virus (RLV), and LP-BM5 (murine AIDS) virus infection in mice, feline leukemia virus (FeLV) or feline immunodeficiency virus (FIV) infection in cats, and SIV infection in macaque (rhesus) monkeys (for review, see Ref. 53). In the latter model [54], again PMEA proved far superior to AZT in suppressing several parameters of the disease. 

Fig. 11. Structures of oncoretrovirus receptor-binding domains. Left The receptorbinding domain of Friend murine leukemia virus (Fass et al, 1997). Right The homologous domain from subgroup B feline leukemia virus (Barnett et al, 2003). The positions of the variable subdomains and conserved /9-sandwich scaffold are indicated. The histidine residue critical for receptor binding-induced activation of membrane fusion by this virus group is indicated at the extreme amino terminus in the feline leukemia virus structure, but this residue was not seen in the electron density of the Friend receptor-binding domain.

Eurifel FELV (vaccine consisting of an engineered canarypox virus into which the gag, env and a partial pol gene of feline leukemia virus have been inserted) Merial Immunization of cats against feline leukemia virus 2000... 

Wheeler, E.F. Roussel, M.F. Hampe, A. Walker, M.H. Fried, V.A. Look, A.T. Rettenmier, C.W. Sherr, C.J. The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences. J. Virol., 59, 224-233 (1986)... 

Weinbersterols disodium sulfate A (284), B (285) Sponge, Petrosia weinbergi Feline leukemia virus, HIV-I Uknown [208]... 

Over 195 patents have been filed since 1986 in which zidovudine (152) is mentioned. Potent side effects preclude the widespread use of zidovudine against the AIDS virus. In addition to having activity against the AIDS virus, zidovudine has activity against the feline leukemia virus and gramnegative bacterial infections <86EUP199451, 86EUP217580>. 

MLV-related virus (spleen necrosis virus, mouse, and feline leukemia viruses). 

Clark N, Kushner NN, Barrett CB, Kensil CR, Salsbury D, Cotter S (1991) Efficacy and safety field trials of a recombinant DNA vaccine against feline leukemia virus infection. J Amer Veterin Med Assoc 199 1433-1443... 

Abbreviations Ad, Adenovirus EBV, Epstein-Barr virus FeLV, Feline leukemia virus FeSV, Feline sarcoma virus GaLV, Gibbon ape lymphosarcoma virus HVA, Herpesvirus ateles HVS, Herpesvirus saimiri MV, Monkey virus PML, Progressive multifocal leukoencephalopathy associated with three SV40-like viruses SSV-1, Woolly monkey fibrosarcoma virus SV, Simian virus. [Adapted from (477)]. 

Gunasekera, S.P. and Cross, S.S. (1992) Fistularin 3 and 11-ketofistularin 3. Feline leukemia virus active bromotyrosine metabolites from the marine sponge Aplysina archeri. J. Nat. Prod., 55, 509-512. 

Derived from human immunodeficiency virus, equine infectious anemia virus, or feline leukemia virus. Experience with helper-dependent adenoviral vectors is limited. 

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