Antagonists serotonin

Serotonin antagonist Serotomnergic agents Serotomnergic neurons Serotonin receptors Seroxat Serpak process Serpasil Serpentine... 

Altanserin (100) is a representative of the thiaquinazolinones. This serotonin antagonist is said to prevent gastric lesions. One method for preparation of this compound involves first preparation of isothiocyanate derivative 99, by reacting 4-fluorobenzoylpiperidine with 2-bromoethylamine and then converting the intermediate to the isothiocyanate with thionyl chloride and base. Condensation of 99 with methyl anthranilate (98) probably proceeds initially to a thiourea. Cyclization by ester-amide interchange leads to altanserin (100) [28]. 

The involvement of serotonin (5-hydroxytryptamine) in disease states has been recognized for several decades. Research on antagonists awaited the recent development of methodology involving serotonin receptors. A thiazolopyrimidone serves as the nucleus for a pair of serotonin antagonists. The key intermediate 118 is in fact simply the lactonized form of 2-hydroxyethyl acetoace-tate. Condensation of this P-keto ester can be visualized to involve initial attack on the reactive... 

Antipsychotics (conventional agents have nonspecific dopamine receptor antagonsim atypical agents also have serotonin antagonist activity), ecopipam, GBR-12909 and other partial dopamine agonists (may be functional antagonists)... 

Telomerase Tyrosinase inhibitor Sildenafil Serotonin antagonist... 

QUESTION Have you made any attempt to antagonize the MBDB stimulus with serotonin antagonists ... 

MAOI, monoamine oxidase inhibitor SARI, serotonin antagonist and reuptake inhibitor SNRI, serotonin and norepinephrine reuptake inhibitor SSRI, selective serotonin reuptake inhibitor TCA, tricyclic antidepressant. 

Histamine-receptor Antagonists Serotonin agonists Serotonin antagonists Ergot alkaloids... 

Short-term toxicities of adjuvant chemotherapy are generally well tolerated, especially with the availability of serotonin-antagonist and substance P/neurokinin 1-antagonist antiemetics and colony-stimulating factors. 

Haigler, H. J., and Aghajanian, G. K. (1974) Peripheral serotonin antagonists Failure to antagonize serotonin in brain areas receiving a prominent serotonergic input. J Neural Transm., 35 257-274. 

Proudfit, FI. K., and Anderson, E. G. (1974) New long latency bulbospinal evoked potentials blocked by serotonin antagonists. Brain Res., 65 542-546. 

Mclsaac, W. M., Khairallah, P. A., and Page, 1. H. (1961) 10-Methoxyharmalan, a potent serotonin antagonist which affects conditioned behavior. Science, 134 674-675. 

Direct evidence is also available from functional studies that LSD can act as a serotonin antagonist. Anderson (9) has reviewed experiments on spinal reflexes conducted in acute spinal cats in which stimulation of the dorsal roots elicits monosynaptic, polysynaptic, and dorsal root reflexes. Increases in CNS levels of serotonin increased the size of the monosynaptic reflex and decreased the size of the polysynaptic and dorsal root reflexes. The increase in magnitude of the monosynaptic reflex induced by serotonin was blocked by a variety of classic serotonin antagonist drugs in addition, it was blocked by the systemic administration of LSD. Decreases in the other two types of spinal reflexes were unaffected by LSD and the serotonin antagonists. 

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