Murine leukemia virus

Wang, J., and Baltimore, D. (1983). Cellular RNA homologous to the Abelson murine leukemia virus transforming gene expression and relationship to the viral sequence. Mol. Cell. Biol. 3 773-779. 

FIGURE 8.13 Nonreceptor PTKs. These protein kinases form a large family, and most of them contain SH2 and SH3 domains. Several were originally discovered as transforming genes of a viral genome, hence names such as src or abl, derived from Rous sarcoma virus or Abelson murine leukemia virus, respectively. (Adapted from Hunter, T., Biochem. Soc. Trans., 24(2), 307-327, 1996.)... 

Dunkel VC, Pienta RJ, Sivak A, et al. 1981. Comparative neoplastic transformation responses of Balb/3T-3 cells, Syrian hamster embryo cells, and Rauscher murine leukemia virus-infected Fischer 344 rat embryo cells to chemical carcinogens. J Nat Cancer Inst 67 1303-1315. 

Abelson murine leukemia virus abi Tyrosine kinase... 

Wang S, Crute BE, Melnikova IN, Keller SR, Speck NA. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol 1993 13 3324-3339. 

Hein, S., Prassolov, V., Zhang, Y., Ivanov, D., Lohler, J., Ross, S.R. and Stocking, C. (2003) Sodium-dependent myo inositol transporter 1 is a cellular receptor for Mus cervicolor M813 murine leukemia virus. J Viroin, 5926-5932. 

Klement, V., Rowe, W., Hartley, J. and Pugh, W. (1969) Mixed culture cytopathogenicity A new test for growth of murine leukemia viruses in tissue culture. Proc. Natl. Acad. Sci, USA 63, 753-758. 

Miller, A. and Chen, F. (1996) Retrovirus packaging cells based on lOAl murine leukemia virus for production of vectors that use multiple receptors for cell entry. J VlrollO, 5564-5571. 

Tailor, C., Nouri, A., Lee, C., Kozak, C. and Kabat, D. (1999) Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses. Proc. Natl. Acad. Sci, USA 96, 927-932. 

The detection of HIV-related proteins is one of the most challenging tasks. This is especially true because AIDS should be diagnosed as early as possible to enable an early and effective therapy of this infection. Pavski and Le (57) used the aptamer strategy to detect reverse transcriptase (RT) of the type 1 human immunodeficiency virus (HIV-1). A direct and specific ACE method was proposed using laser-induced fluorescence (ACE/LIF) as detection principle. Single-stranded DNA aptamers as probes fluorescently labeled were synthesized. The resulting aptamer is specific for HIV-1 RT, and it exhibited no cross-reactivity with RTs of the enhanced avian myeloblastosis virus (AMV), the Moloney murine leukemia virus (MMLV), or denatured HIV-1 RT. An affinity complex of RT 26-HIV-l RT was stable, with calibration curves linear up to 50 nM (6 /xg/mL) HIV-1 RT concentration. Both... 

Results from testing against a variety of polymerase enzymes show that efavirenz is inactive up to 300 p,M for a 50% inhibition (Young et al., 1995). The polymerase enzymes studied were Moloney murine leukemia virus RT, human DNA polymerases a, 3, and 7, Escherichia coli RNA polymerase, and the Klenow fragment. Cytotoxicity studies in their primary cells and in a T-cell line reveal that efavirenz has a selectivity index of 80,000. 

AntivertigO effect. Powdered rhizome, administered orally to human adults at a dose of 1 g/person, was active vs seasickness ° k Rhizome, administered orally to adults of both sexes at a dose of 1 g/person, was inactive. The treatment was administered 2 hours before the subjects were rotated in a chair making head movement until a symptom short of vomiting was reached ° Antiviral activity. Aqueous low-speed supernatant of the rhizome, at a concentration of 1% and the rhizome juice, produced strong activity on virus-top necrosis h Decoction of the rhizome together with c at a concentration of 250 pg/mL, was active on HlV-1 and Rauscher murine leukemia viruses. Reverse transcriptase activity was inhibited . Water extract of the rhizome, in cell culture at a concentration of 10%, was inactive on herpes virus type 2, A2-... 

Reverse transcriptase activity. Water extract of Zingiber officinale (Rh), Bupleurum falcatum, Scutellaria baicalensis (Rt), Pinellia ternata (Tu), Zizyphus jujuba (Fr), Panax gim seng (Rt), and Glycyrrhiza glabra (Rh), at a concentration of 200 pg/mL, was active on Moloney murine leukemia virus and HlVzo2 L... 

The most common retroviral vector is based on the amphotropic Moloney murine leukemia virus (MLV) (31). This system is particularly suitable for efficient in vitro cell transduction the amphotropic MLV has a broad cell tropism, it can be produced at relatively high titers (106—107 iu/mL), and allows for long-term transgene expression because of the viral integration in the host chromosomal DNA. 

Shinnick, T.M., Lemer, R.A., Sutcliffe, J.G. (1981). Nucleotide sequence of Moloney murine leukemia virus. Nature, 293, 543-548. 

Carteau S, Mouscadet JF, Goulaouic H, Subra F, Auclair C. Inhibition of the in vitro integration of Moloney murine leukemia virus DNA by the DNA minor groove binder netropsin. Biochem Pharmacol... 

Georgiadis MM, lessen SM, Ogata CM, Telesnitsky A, Goff SP, Hendrickson WA. Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase. Structure 1995 3 879-892. 

Tanese N, Goff SP. Domain structure of the Moloney murine leukemia virus reverse transcriptase mutational analysis and separate expression of the DNA polymerase and RNase H activities. Proc Natl Acad Sci USA 1988 85 1777-1781. 

Tanese NT, Telesnitsky A, Goff SP. Abortive reverse transcription by mutants of Moloney murine leukemia virus deficient in the reverse transcriptase-associated RNase H function. J Virol 1991 65 4387-4397. 

Irons, R.D. (1990) Studies on the mechanism of 1,3-butadiene-induced leukemogenesis the potential role for endogenous murine leukemia virus. Environ. Health Perspect., 86, 49-55... 

Warren, W, Clark, J.P, Gardner, E., Harris, G, Cooper, C.S. Lawley, PD. (1990) Chemical induction of thymomas in AKR mice interaction of chemical carcinogens and endogenous murine leukemia viruses. Comparison of W-methyl-A-nitrosourea and methyl methane-sulphonate. Mol. Carcinog., 3, 126-133... 

Confirming the importance, for the biological activity,10-n of a keto group in the sugar moiety, the antiviral activity of some keto-C-nucleo-sides has also been reported.13 From this study, it was clear that the presence of a ketone group in these nucleosides, as in 4 -ketonucleoside 50a, gave a compound able to inhibit the replication of murine leukemia virus at nontoxic concentrations. 

---