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Protein Engineering engineered

Because this problem is complex several avenues of attack have been devised in the last fifteen years. A combination of experimental developments (protein engineering, advances in x-ray and nuclear magnetic resonance (NMR), various time-resolved spectroscopies, single molecule manipulation methods) and theoretical approaches (use of statistical mechanics, different computational strategies, use of simple models) [5, 6 and 7] has led to a greater understanding of how polypeptide chains reach the native confonnation. [Pg.2642]

Van Aalten, D.M.F., Findlay, J.B.C., Amadei, A., Berendsen,H.J.C. Essential dynamics of the cellular retinol-binding protein. Evidence for ligand-induced conformational changes. Protein Engin. 8 (1995) 1129-1136. [Pg.35]

Finkelslain A V 1997. Can Protein Unfolding Simulate Protein Folding Protein Engineering 10 843... [Pg.575]

Orengo C A, T P Flores W R Taylor and J M Thornton 1993. Identification and Oassificalion of Prc Fold Families. Protein Engineering 6 485-500. [Pg.577]

Aqvist J, C Medina and J-E Samuelsson 1994. A New Method for Predicting Binding Affinity Computer-aided Drug Design. Protein Engineering 7 385-391. [Pg.649]

Hansson T and J Aqvist 1995. Estimation of Binding Free Energies for HIV Proteinase Inhibitors b Molecular Dynamics Simulations. Protein Engineering 8 1137-1144. [Pg.651]

Biological catalysts — enzymes — are usually proteins. The development of new protein syntheses is nowadays dominated by genetic protein engineering (see section 4.1.2.6). Bio-organic approaches towards novel catalytically active structures and replicating systems try to manage without biopolymers. [Pg.346]

Robson, B. Gamier, J. 1986, Introduction to Proteins and Protein Engineering, Elsevier Amsterdam... [Pg.377]


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