Supramolecular protein engineering

M.A. (2010) Supramolecular protein engineering design of zinc-stapled insulin hexamers as a long acting depot. Journal of Biological Chemistry, 285, 11755-11759. 

The design of supramolecular catalysts may make use of biological materials and processes for tailoring appropriate recognition sites and achieving high rates and selectivities of reactions. Modified enzymes obtained by chemical mutation [5.70] or by protein engineering [5.71] represent biochemical approaches to artificial catalysts. 

So far, peptide synthesis has mainly involved the preparation of biologically or pharmaceutically relevant substances, total chemical synthesis of natural proteins or protein engineering. The objective of this chapter is to show how the different methods that have been developed for peptide synthesis can be used to prepare biologically-inspired supramolecular architectures and polymeric materials, which might be of potential interest for a variety of advanced applications. 

Peptide ligation strategies used so far have mainly been used for protein total synthesis and protein engineering purposes. The ability to prepare perfectly mono-disperse and relatively high molar mass peptides with precise control over the a-amino acid sequence could also afford unprecedented opportunities for the development of novel biologically-inspired supramolecular architectures and materials. As a final, recent, example, the preparation of a protein[2]catenane using NCL is shown in Figure 6.6.5 [34]. 

Therapeutic gold complexes, 12 700-701 Therapeutic index, 18 252 Therapeutic pet foods, 10 849 Therapeutic products, from genetically engineered microbes, 12 480 Therapeutic proteins, 3 816 Therapeutics, supramolecular chemistry in, 24 56-57... 

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