Polyethylene glycols ointment

Melt the stearyl alcohol and white petrolatum (steam bath) and warm to about 75°C. Heat the water to 75°C and add the sodium lauryl sulfate, propylene glycol, methylparaben, and propylparaben. Add the aqueous phase and stir until congealed. IV. Water-soluble ointment (polyethylene glycol ointment, USP 14) Polyethylene glycol 4000 (Carbowax 4000) 50%... 

Hadia, I. A., Ugrine, H. E., Farouk, A. M., and Shayoub, M. (1989), Formulation of polyethylene glycol ointment bases suitable for tropical and subtropical climates I. Acta Pharm. Hung., 59,137-142. 

IV. Water-soluble ointment (polyethylene glycol ointment, USP 14)... 

Each gram of mupirocin ointment 2% contains 20 mg mupirocin in a bland water-miscible ointment base (polyethylene glycol ointment NF) consisting of polyethylene glycol 400 and polyethylene glycol 3350. Mupirocin is a naturally occurring antibiotic. The nasal ointment 2% contains the dihydrate crystalline calcium hemisalt of the... 

Elbary et al. [114] have correlated the spermicidal efficacy and the hemolytic index of the saponin fraction of Gypsophila paniculata and saponins derived from other plants. Gypsophila saponins were relatively superior when used either as aqueous solution or as formulation in polyethylene glycol ointment base. 

The anhydrous petrolatum base may be made more miscible with water through the use of an anhydrous liquid lanolin derivative. Drugs can be incorporated into such a base in aqueous solution if desired. Poly-oxyl 40 stearate and polyethylene glycol 300 are used in an anti-infective ointment to solubilize the active principle in the base so that the ointment can be sterilized by aseptic filtration. The cosmetic-type bases, such as the oil-in-water (o/w) emulsion bases popular in dermatology, should not be used in the eye, nor should liquid emulsions, owing to the ocular irritation produced by the soaps and surfactants used to form the emulsion. 

Simone and Popino have considered the stability of neomycin in both hydrophobic and hydrophilic ointment bases. No loss of potency over a period of 1 year at 20°C was reported for formulations containing carboxymethylcellulose, polyethylene glycol(P.E.G.) or white-soft paraffin. However, formulations containing hydrous lanolin were reported to be unstable. All materials used in the formulations were obtained from U.S. sources. Coates et al3°l investigated the use of P.E.G. from British sources and described neomycin as being incompatible with the materials tested. 

Hydrogel and water-soluble ointment achieve their consistency by means of different gel-forming agents (gelatin, methylcellulose, polyethylene glycol). Lotions are aqueous suspensions of water-insoluble and solid constituents. 

Intranasal mupirocin in Bactroban Nasal ointment for eliminating nasal carriage of S aureus may be associated with irritation of mucous membranes caused by the polyethylene glycol vehicle. Mupirocin is not appreciably absorbed systemically after topical application to intact skin. 

Ointment An unctuous semisolid for topical application. Typical ointments are based on petrolatum. An ointment does not contain sufficient water to separate into a second phase at room temperature. Water soluble ointments may be formulated with polyethylene glycol. 

This ointment contains both bovine pancreatic DNase I as well as a fibrinolytic complex formulated in a mixture of polyethylene glycol and paraffin oil [85]. 

Water-soluble bases do not contain any oily or oleaginous phase. Solids can be easily incorporated into these bases. They may be completely removed from the skin due to their water solubility. Polyethylene glycol (PEG) ointment National Formulary (NF) is an example of a water-soluble base. 

Watei oluble ointments include mixtures of mac-rogols and polyethylene glycols their consistency can be varied readily. They are easily washed off and are used in bum dressings, as lubricants and as vehicles that readily allow passage of dmgs into the skin, e.g. hydrocortisone. 

Before the middle of the 1970s, a few synthetic polymers found applications in the pharmaceutical industry, such as polyvinyl pyrrolidone and polyvinyl alcohol for oral formulations, polyethylene glycol and polyethylene (PE) for ointments, and polyacrylic acid for poultice. Nowadays, following the development of the drug delivery system (DDS), more varied synthetic polymers are applied in formulation studies. Because DDS concentrates on increasing the therapeutic effectiveness of... 

Ointments are composed mostly of fluid hydrocarbons meshed in a mafrix of higher melting solid hydrocarbons. Common examples of ointment bases include mineral oil, petrolatum, and polyethylene glycol. Creams are semisolid emulsion systems with an opaque... 

Smyth HF, Carpenter CP, Weil CS. The chronic oral toxicology of the polyethyleneglycols./ Am Pharm Assoc (Sci) 1955 44 27-30. Fisher AA. Immediate and delayed allergic contact reactions to polyethylene glycol. Contact Dermatitis 1978 4 135-138. Anonymous. Topical PEG in burn ointments. FDA Drug Bull 1982 12 25-26. 

Polyethylene glycol (PEG) Polymer widely used in pharmacy os on ointment bo.se. It has been used as a. soluble support and as a linker in combinalorial synthesis. Its. structure is... 

Mupirocin is supplied in u wulcr-miscible ointment con-uming 2Vo of the antibiotic in polyethylene glycols 400 and 350. 

Adverse reactions arc few. Some patients experience w-ca.sional gastrointestinal up.set. di/z.ines.s. headache, lethargy. and joint pain. An ointment composed of S% acyclovir in a polyethylene glycol base is available for the treatment of initial, mild episodes of herpes genitalis. The ointment is not an effective preventer of recurrent episodes. 

Polyethylene glycols are widely used in food, cosmetics, and topical pharmaceuticals (e.g., ointments and suppository base). 

Polyethylene glycols (PEGs) have also found use in topical preparations, though are generally used in emulsions and ointments. Molecular weights ranging from 200 up to 8000 have been selected and included at levels typically up to about 60%. Smaller polyethylene glycols have also been selected as solvents and... 

Since 1969, bovine pancreatic DNase I has been used for the treatment of ulcers in dermatology [82-84]. It degrades the polynucleotides that are a main constituent of dead cells. One dermatological product based on DNase I is Elase . This ointment contains both bovine pancreatic DNase I as well as a fibrinolytic complex formulated in a mixture of polyethylene glycol and paraffin oil [85],... 

Acyclovir is available for topical application (Zovirax ointment 5% 50 mg/kg in a polyethylene glycol base), which may cause mucosal irritation and transient burning when applied to genital lesions. 

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