Mupirocin ointment

Didoxacillin 25-50 mg/kg in four divided doses Cephalexin 25-50 mg/kg in two to four divided doses Cefadroxil 30 mg/kg in two divided doses Clindamycin 10-30 mg/kg/day in three to four divided doses0 Mupirocin ointment every 8 hours0... 

Spontaneous rupture of polyurethane peritoneal catheter has been attributed to mupirocin ointment (2). 

An 84-year-old man with diabetic nephropathy and end-stage renal disease began continuous ambulatory peritoneal dialysis and over the next year had four episodes of exit-site infection and peritonitis and used mupirocin ointment. The exit-site catheter became dilated and during an episode of infection for which he used mupirocin on 6 successive days, a longitudinal rupture developed in the peritoneal catheter, which was removed. The peritoneal liquid contained Escherichia coli and Proteus mirabilis and the catheter tip contained E. coli and Enterobacter cloacae. He was treated with ciprofloxacin, without complications, and after 1 month a new peritoneal catheter was inserted. 

Mupirocin ointment can occasionally cause allergic contact dermatitis (3). 

Riu S, Ruiz CG, Martinez-Vea A, Peralta C, Oliver JA. Spontaneous rupture of polyurethane peritoneal catheter. A possible deleterious effect of mupirocin ointment. Nephrol Dial Transplant 1998 13(7) 1870-1. 

Zappi EG, Brancaccio RR. Allergic contact dermatitis from mupirocin ointment. J Am Acad Dermatol 1997 36(2 Pt 1) 266. 

Each gram of mupirocin ointment 2% contains 20 mg mupirocin in a bland water-miscible ointment base (polyethylene glycol ointment NF) consisting of polyethylene glycol 400 and polyethylene glycol 3350. Mupirocin is a naturally occurring antibiotic. The nasal ointment 2% contains the dihydrate crystalline calcium hemisalt of the... 

Jagota, N.K. Stewart, J.T. Warren, F.W. John, P.M. Stability of mupirocin ointment (Bactroban) admixed with other proprietary dermatological products. J.Clin.Pharm.Ther., 1992, 17, 181—184... 

Yano, M., Doki, Y., Inoue, M., Tsujinaka, T., Shiozaki, H., and Monden, M. (2000) Preoperative intranasal mupirocin ointment significantly reduces postoperative infection with Staphylococcus aureus in patients undergoing upper gastrointestinal surgery. Surg. Today (Japan) 30, 16-21. 

Exit site infections are common and are recognized by redness, exudation and crusting. Topical agents applied to catheter exit site, such as povidone iodine, mupirocin, bacitracin zinc and polymixin B sulphate ointments have been proven effective [20, 21]. Oral rifampin or nasal mupirocin ointment reduced the incidence of S. aureus bacteremia [22]. 

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