Anhydrous petrolatum base

The anhydrous petrolatum base may be made more miscible with water through the use of an anhydrous liquid lanolin derivative. Drugs can be incorporated into such a base in aqueous solution if desired. Poly-oxyl 40 stearate and polyethylene glycol 300 are used in an anti-infective ointment to solubilize the active principle in the base so that the ointment can be sterilized by aseptic filtration. The cosmetic-type bases, such as the oil-in-water (o/w) emulsion bases popular in dermatology, should not be used in the eye, nor should liquid emulsions, owing to the ocular irritation produced by the soaps and surfactants used to form the emulsion. 

Ointments, ophthalmic. Sterile ointments designed for application to the eyelids. Petrolatum, petrolatum-mineral oil, and petrolatum-anhydrous lanolin bases are often used in ophthalmic ointments because of their low irritating potential. Finely powdered, sterile active ingredients are aseptically incorporated into a sterile base, using sterile utensils, and dispensed in sterile ophthalmic-tipped tubes to reduce the possibility of contamination. ... 

Example 4 Hydrophilic petrolatum, USP (anhydrous absorption base)... 

Menthol, camphor, or similar substances can be mixed to form a eutectic mixture, which can be absorbed onto wool fat (anhydrous lanolin), and then incorporated into the intended base. If such ingredients are not provided as mixtures, they can be dissolved in warm liquid petrolatum or vegetable oil before being incorporated into the base. 

Ointments are similar to creams but may be more viscous. Many ointments are prepared from a base of anhydrous lanolin or white petrolatum, which is a mixture ofn-, iso-, and cyclic-paraffins. Waxes may be added to make the ointments harder. 

In its strictest definitive form, an ointment is classified as any semi-solid containing fatty material and intended for external application (U.S. Pharmocopeia, USP). In this discussion, ointments will be defined as semisolid anhydrous external preparations. In the nineteenth century, ointments were based on lard, a compounding material, the usefulness of which was severely limited by its tendency to turn rancid. Early in the twentieth century, lard was replaced by petrolatum (white or yellow soft paraffin or petroleum jelly). In present practice, nonmedicated ointments (ointment bases) are used alone, for emollient or lubricating purposes, or in combination with a drug for therapeutic purposes. 

H20. Cream contains calcipotriene monohydrate equivalent to 50 pg/g anhydrous calcipotriene in a cream base of cetearyl alcohol, ceteth-20, diazolidinyl urea, dichlo-robenzyl alcohol, dibasic sodium phosphate, edetate disodium, glycerin, mineral oil, petrolatum, and water. 

The ointment is an enzymatic debriding-healing ointment that contains standardized papain USP (not less than 521,700 USP units per gram of ointment), urea USP 10%, and chlorophyllin copper complex sodium 0.5% in a hydrophilic base composed of purified water USP, propylene glycol USP, white petrolatum USP, stearyl alcohol NF, polyoxyl 40 stearate NF, sorbitan monostearate NF, boric acid NF, chlorobutanol (anhydrous) NF (as a pre-... 

Foundations are usually mixtures of a suspension and an emulsion (termed sus-poemulsiori) in which the emulsion portion is usually either O/W or W/O and the continuous phase generally contains the pigment particles. Foundations need to be formulated to be thixotropic to provide the desired smooth levelling effect. Ointments are similar to creams but may be more viscous. Many ointments are prepared from a base of anhydrous lanolin or white petrolatum, which is a mixture of iso- and cyclic paraffins. Waxes may be added to make the ointments harder. 

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