Ointment bases polyethylene glycol

Each gram of mupirocin ointment 2% contains 20 mg mupirocin in a bland water-miscible ointment base (polyethylene glycol ointment NF) consisting of polyethylene glycol 400 and polyethylene glycol 3350. Mupirocin is a naturally occurring antibiotic. The nasal ointment 2% contains the dihydrate crystalline calcium hemisalt of the... 

The anhydrous petrolatum base may be made more miscible with water through the use of an anhydrous liquid lanolin derivative. Drugs can be incorporated into such a base in aqueous solution if desired. Poly-oxyl 40 stearate and polyethylene glycol 300 are used in an anti-infective ointment to solubilize the active principle in the base so that the ointment can be sterilized by aseptic filtration. The cosmetic-type bases, such as the oil-in-water (o/w) emulsion bases popular in dermatology, should not be used in the eye, nor should liquid emulsions, owing to the ocular irritation produced by the soaps and surfactants used to form the emulsion. 

Simone and Popino have considered the stability of neomycin in both hydrophobic and hydrophilic ointment bases. No loss of potency over a period of 1 year at 20°C was reported for formulations containing carboxymethylcellulose, polyethylene glycol(P.E.G.) or white-soft paraffin. However, formulations containing hydrous lanolin were reported to be unstable. All materials used in the formulations were obtained from U.S. sources. Coates et al3°l investigated the use of P.E.G. from British sources and described neomycin as being incompatible with the materials tested. 

Ointment An unctuous semisolid for topical application. Typical ointments are based on petrolatum. An ointment does not contain sufficient water to separate into a second phase at room temperature. Water soluble ointments may be formulated with polyethylene glycol. 

Water-soluble bases do not contain any oily or oleaginous phase. Solids can be easily incorporated into these bases. They may be completely removed from the skin due to their water solubility. Polyethylene glycol (PEG) ointment National Formulary (NF) is an example of a water-soluble base. 

Hadia, I. A., Ugrine, H. E., Farouk, A. M., and Shayoub, M. (1989), Formulation of polyethylene glycol ointment bases suitable for tropical and subtropical climates I. Acta Pharm. Hung., 59,137-142. 

Ointments are composed mostly of fluid hydrocarbons meshed in a mafrix of higher melting solid hydrocarbons. Common examples of ointment bases include mineral oil, petrolatum, and polyethylene glycol. Creams are semisolid emulsion systems with an opaque... 

Adverse reactions arc few. Some patients experience w-ca.sional gastrointestinal up.set. di/z.ines.s. headache, lethargy. and joint pain. An ointment composed of S% acyclovir in a polyethylene glycol base is available for the treatment of initial, mild episodes of herpes genitalis. The ointment is not an effective preventer of recurrent episodes. 

Polyethylene glycols are widely used in food, cosmetics, and topical pharmaceuticals (e.g., ointments and suppository base). 

Since 1969, bovine pancreatic DNase I has been used for the treatment of ulcers in dermatology [82-84]. It degrades the polynucleotides that are a main constituent of dead cells. One dermatological product based on DNase I is Elase . This ointment contains both bovine pancreatic DNase I as well as a fibrinolytic complex formulated in a mixture of polyethylene glycol and paraffin oil [85],... 

Acyclovir is available for topical application (Zovirax ointment 5% 50 mg/kg in a polyethylene glycol base), which may cause mucosal irritation and transient burning when applied to genital lesions. 

Elbary et al. [114] have correlated the spermicidal efficacy and the hemolytic index of the saponin fraction of Gypsophila paniculata and saponins derived from other plants. Gypsophila saponins were relatively superior when used either as aqueous solution or as formulation in polyethylene glycol ointment base. 

Lead oxide, yellow Polyethylene glycol Storax (Liquidambar orientalis) Zinc stearate ointment base, pharmaceuticals Cetyl palmitate Cocamidopropyl betaine Lanolin ointment mfg. 

Similar changes may be seen for ointment bases such as polyethylene glycol (e.g. PEG 6000 Figure 23). The lower enthalpies of the second scan are due to an increased amorphousness in the samples. Certainly for PEG this suggests... 

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