Pleural mesothelioma

Vogelzang, N.J. et al.. Phase III study of pemetrexed in combination with cisplatm versus cis-platin alone in patients with malignant pleural mesothelioma, /. Clin. Oncol, 21, 2636-2644, 2003. 

Baris, Y. 1., M. Ozemsi, I. Kerse, E. Ozen, A. Sahin, B. Kolacan, and M. Ogan-kulu (1975). An outbreak of pleural mesothelioma in the village of Karain/ Uregup-Anatolia. Medicine Biologic /Environment 3 5—11. 

The morphological features of pleural mesothelioma have been invest -... 

Peto, J. (1980). The incidence of pleural mesothelioma in chrysotilc asbestos textile workers, pp. 703-771. In Biological Effects of Mineral Fibers, Vol. 2, WHO/... 

Wagner, J. C., C. A. Sleggs, and P. Marchand (1960). Diffuse pleural mesothelioma and asbestos exposure in the Northwestern Cape Provice. Br. J. Indust. Med. 17 260-271. 

Wang, N. S. (1973). Electron microscopy in the diagnosis of pleural mesotheliomas. Cancer 31 1046-1054. 

Whitwell, F., J. Scott, and H. Grimshaw (1977). Relationship between occupations and asbestos fiber content of the lungs in patients with pleural mesothelioma, lung cancer and other diseases. Thorax 32 377-386. 

Pemetrexed is chemically similar to folic acid. It inhibits three enzymes used in purine and pyrimidine synthesis - thymidylate synthetase, dihydrofolate reductase, and glycinamide ribonucleotide formyl transferase. By inhibiting the formation of precursor purine and pyrimidine nucleotides, pemetrexed prevents the formation of DNA and RNA. In 2004 it was approved for treatment of malignant pleural mesothelioma and as a second-line agent for the treatment of non-small cell lung cancer. Adverse effects include gastrointestinal complaints, bone marrow suppression, alopecia, allergic and neurotoxic reactions. 

Elshami, A. A., Kucharczuk, J. C., Zhang, H. B., Smythe, W. R., Hwang, H. C., Litzky, L. A., Kaiser, L. R. and Albelda, S. M. (1996). Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene. Hum. Gene Ther. 7, 141-148. 

Frebourg, T. et al., Serum hyaluronate in malignant pleural mesothelioma, Cancer, 59, 2104, 1987. 

Zanellato I, Heldt J-M, Vessieres A, Jaouen G, Osella D (2009) Antiproliferative effect of ferrocifen drug candidates on malignant pleural mesothelioma cell lines. Inorg Chim Acta 362 4037 1042... 

M (CEL increased SMRs for lung cancer pleural mesothelioma)... 

McDonald and McDonald 1980 Voisin et al. 1994). As with other asbestos-related respiratory health effects, asbestos-induced mesothelioma appears to have a long latent period of development. For example, Anderson et al. (1976) described two cases of women who presumably experienced household contact with asbestos as children, when their fathers worked with asbestos, and developed clinically detected pleural mesothelioma more than 30 years later. In a review of 1,105 cases of malignant mesotheliomas associated with occupational exposure to asbestos, Lanphear and Buncher (1992) reported that 99% had a latent period >15 years, and calculated a median latent period of 32 years. 

Comparative Toxicokinetics. Available data Ifom ehronic rat inhalation bioassays show similar asbestos-induced respiratory effects to those in humans assoeiated with oeeupational exposure to asbestos (pulmonary fibrosis, lung cancer, and pleural mesothelioma), but the use of the rat data to predict human health risks from exposure to airborne asbestos has a number of areas of uneertainty, including those associated with interspecies differences in lifespan, airway morphometry, and breathing patterns. The development of rat and human lung retention models that incorporate species differences in anatomical and physiological parameters influencing deposition and clearance of asbestos fibers may decrease the... 

Andersson E, Toren K. 1995. Pleural mesotheliomas are underreported as occupational cancer in Sweden. Am J Ind Med 27 577-580. 

Bianchi C, Brollo A, Ramani L, et al. 1997. Pleural plaques as risk indicators for malignant pleural mesothelioma A necropsy-based study. Am J Ind Med 32 445-449. 

Booth SJ, Weaver EJ. 1986. Malignant pleural mesothelioma five years after domestic exposure to blue asbestos [Letter], Lancet 1 435. 

Cazzadori A, Malesani F, Romeo L. 1992. Malignant pleural mesothelioma caused by non-occupational childhood exposure to asbestos. Br J hid Med 49 599... 

Chailleux E, Pioche D, Chopra S, et al. 1995. [The epidemiology of malignant pleural mesothelioma in the Nantes-Saint-Nazaire region. Evolution between 1956 and 1992]. Rev Mai Resp 12 353-357. 

Dodoli D, Del Nevo M, Fiumalbi C, et al. 1992. Enviromnental household exposures to asbestos and occurrence of pleural mesothelioma. Am J Ind Med 21 681-687. 

Dumortier P, Rey F. 1998. RE main asbestos type in pleural mesothelioma [Letter]. Am J Ind Med... 

Enterline PE, Henderson VL. 1987. Geographic patterns for pleural mesothelioma deaths in the United States, 1968-81. J Natl Cancer Inst 79 31-37. 

Erzen C, Eryilmaz M, Kalyoncu F, et al. 1991. CT findings in malignant pleural mesothelioma related to nonoccupational exposure to asbestos and fibrous zeolite (erionite). J Comput Assist Tomogr 15 256-260. 

Gennaro V, Ceppi M, Boffetta P, et al. 1994. Pleural mesothelioma and asbestos exposure among Italian oil refinery workers. Scand J Work Environ Health 20 213-215. 

Huncharek M, Muscat J. 1991. Metastatic laryngeal carcinoma mimicking pleural mesothelioma. Respiration 58(3-4) 204-206. 

Huncharek M, Kelsey K, Muscat J, et al. 1996. Parental cancer and genetic predisposition in malignant pleural mesothelioma A case-control study. Cancer Lett 102 205-208. 

Inase N, Takayama S, Nakayama M, et al. 1991. Pleural mesothelioma after neighborhood exposure to asbestos during childhood. Jpn J Med 30(4) 343-345. 

Iwatsubo Y, Pairon JC, Boutin C, et al. 1998. Pleural mesothelioma Dose-response relation at low levels of asbestos exposure in a French population-based case-control study. Am J Epidemiol 148 133-142. 

Jarvholm B, Malker H, Malker B, et al. 1988. Pleural mesotheliomas and asbestos exposure in the pulp and paper industries A new risk group identified by linkage of official registers. Am J Ind Med 13 561-567. 

Johnson NF, Wagner JC, Brown DG, et al. 1982. The ultrastmcture of asbestos induced rat pleural mesotheliomas following transplantation into syngeneic animals [Abstract], J Pathol 137 80. 

Kawai A, Nagasaka Y, Muraki M, et al. 1997. Brain metastasis in malignant pleural mesothelioma. 

Kinnula VL, Linnala A, Viitala E, et al. 1998. Tenascin and fibronectin expression in human mesothelial cells and pleural mesothelioma cell-line cells. Am J Respir Cell Mol Biol 19 445-452. 

Langer AM, Nolan RP, Constantopoulos SH, et al. 1987. Association of Metsovo lung and pleural mesothelioma with exposure to tremolite-containing whitewash. Lancet l(8539) 965-967. 

Lilienfeld DE. 1991a. Asbestos-associated pleural mesothelioma in school teachers A discussion of four cases. Ann NY Acad Sci 643 454-486. 

McLean AN, Patel KR. 1997. Clinical features and epidemiology of malignant pleural mesothelioma in west Glasgow 1987-1992. Scott Med J 42 37-39. 

Metintas M, Ozdemir n, Hillerdal G, et al. 1999. Environmental asbestos exposure and malignant pleural mesothelioma. Resp Med 93 349-355. 

Narasimhan SR, Yang B, Gerwin BI, et al. 1998. Resistance of pleural mesothelioma cell lines to apoptosis Relation to expression of Bcl-2 and Bax. Am J Physiol 275 B165-B171. 

Pairon JC, Orlowski E, Iwatsubo Y, et al. 1994. Pleural mesothelioma and exposure to asbestos Evaluation from work histories and analysis of asbestos bodies in bronchoalveolar lavage fluid or limg tissue in 131 patients. Occup Environ Med 51(4) 244-249. 

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