Mesothelioma cell line

Zanellato I, Heldt J-M, Vessieres A, Jaouen G, Osella D (2009) Antiproliferative effect of ferrocifen drug candidates on malignant pleural mesothelioma cell lines. Inorg Chim Acta 362 4037 1042... 

Both K, Turner DR, Henderson DW. 1995. Loss of heterozygosity in asbestos-induced mutations in a human mesothelioma cell line. Environ Mol Mutagen 26 67-71. 

Kinnula VL, Linnala A, Viitala E, et al. 1998. Tenascin and fibronectin expression in human mesothelial cells and pleural mesothelioma cell-line cells. Am J Respir Cell Mol Biol 19 445-452. 

Narasimhan SR, Yang B, Gerwin BI, et al. 1998. Resistance of pleural mesothelioma cell lines to apoptosis Relation to expression of Bcl-2 and Bax. Am J Physiol 275 B165-B171. 

Reale, F. R Griffin, T. W., Compton, J. M., Graham, S., Townes, P. L and Bogden, A. (1987) Characterization of a human malignant mesothelioma cell line (H-MESO-1) A biphasic solid and ascitic tumormodel. Cancer Res. 47,3199-3205. 

Two interferon-Y-controUed metabolic pathways accounting for some of the cytostatic effects of interferon-y in rat pleural mesothelial cells transformed in vitro with benzo[a] pyrene or chrysotile asbestos were not efficient in human mesothelioma cells, and suggested that cytokine-induced growth inhibition is mediated by a different pathway in human mesothelioma cell lines (Phan-Bitch etal. 1997). 

Both cyclooxygenase-2 and inducible nitric oxide synthase were expressed in 30 human mesothelioma tissues but were not detectable in non-reactive mesothelial tissues from the same individuals (Marrogi et al. 2000). In vitro exposure of human mesothelioma cell lines to the COX2 inhibitor, NS398, revealed dose- and time-dependent antiproliferative activity, whereas the NOS2 inhibitor, 1400 W, had no detectable inhibitory effect. 

Mesothelioma cell lines, cultured human primary mesothelial cells... 

Several other candidate cytokine genes are being evaluated for therapeutic effectiveness in animal models of mesothelioma. Caminschi and colleagues at Queen Elizabeth II Medical Center in Perth have investigated genetic alteration of murine mesothelioma cell lines with the gene for IL-12, one ofthe most active... 

Pataer A, Smythe WR, Yu R, Fang B, McDonnell T, Roth JA Swisher SG. Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J Thorac Cardiovasc Surg 2001 121(1 ) 61-67. 

A p-anilyl-substituted an.va-titanocene 48 and titanocene 3 were tested on the growth of a wide variety of tumour cells in vitro on a panel 36 human tumour cell lines containing 14 different tumour types investigated in a cellular proliferations assay [34]. Titanocene 3 showed a significantly higher cytotoxic activity than the ansa-compound and reached, on average over the whole cell panel, the activity of cisplatin within a factor of 4. Nevertheless, there were three main targets for titanocene 3 identified, which are pleura mesothelioma, uterine and renal-cell... 

Erionite has been shown to be an agent responsible for malignant mesothelioma. Mesothelioma is an aggressive tumor of the mesothelial cells lining the body cavities for which there is no cure and for which current therapies to reduce the effects of the disease are unsatisfactory. The source of exposure may be occupational or environmental and 2000-3000 cases are diagnosed per year in the United States, many of which are associated with (amphi-bole) asbestos and erionite. 

The human acute lymphoblastic leukemia CEM cell line and human colon adenocarcinoma LS 174T cell line are available from the American Type Culture Collection (Rockville, MD). The human mesothelioma H-Meso cell line (32) was used previously for cytotoxicity studies (33,34). 

The use of the MEl antibody was initially reported by O Hara and colleagues in 1990. " MEl is a monoclonal antibody generated from the mesothelial cell line SPClll and reacted with normal mesothelial cells and malignant epithelial mesotheliomas. Their antibody was only useful on frozen section tissue and showed immunostaining of 40 of 40 (100%) epithelial mesotheliomas. Nineteen well and moderately differentiated primary pulmonary adenocarcinomas failed to stain with the MEl antibody, but one poorly differentiated pulmonary adenocarcinoma showed intense immunostaining. 

Schwarzenberger P, Lei D, Freeman S, et al. Antitumor activity with the HSV-tk-gene-modified cell line PA-1 -STK in malignant mesothelioma. Am J Respir Cell Mol Biol 1998 19 333-337. 

Schwarzenberger P, Harrison L, Weinacker A, et al. The treatment of malignant mesothelioma with a gene modified cancer cell line a phase 1 study. Hum Gene Ther 1998 9 2641-2649. 

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