Pyrimidine syntheses

Benzofuro[2,3-c]pyridine, 3,4-dihydro-synthesis, 4, 978 Benzofuro[2,3-b]pyridines synthesis, 4, 977 Benzofuro[3,2-b]pyridines synthesis, 4, 981 Benzofuro[3,2-d]pyrimidines synthesis, 4, 987... 

H-l-Benzopyran-4-ones — see Chromones 4H-l-Benzopyran-4-ones, 2-phenyl — see Flavones Benzopyranopyrazoles synthesis, S, 317, 341 Benzopyrano[4,3-c]pytazol-4-one synthesis, 3, 712 Benzopyrano[4,3-6]pyridine synthesis, 3, 712 Benzopyrano[4,3-ii]pyrimidine synthesis, 3, 712 Benzopyrans nomenclature, 1, 23 pyrylium salt synthesis from, 3, 873 reactions... 

Furo[2,3-amino-synthesis, 4, 986 Furo[3,4-d]pyrimidinedione synthesis, 4, 987 Furopyrimidines, 4, 986 Furo[2,3-d]pyrimidines synthesis, 4, 986 Furo[3,2-d]pyrimidines synthesis, 4, 987 Furo[3,2- 6]pyrone synthesis, 4, 994 Furo[3,2-c]pyrone synthesis, 4, 993 Furo[3,2-6]pyrrole, hexahydro-biological activity, 6, 1024 1 H-Furo[3,4-6]pyrrole-2,3-dione, 4,6a-diphenyl-6-(phenylimino)-6,6a-dihydro-synthesis, 6, 1004 Furopyrroles... 

Imidazo[l,2-c]pyrimidine, 2,5,7-trichloro-nucleophilic displacement reactions, 5, 627 Imi dazo[ 1,2-a]pyrimidines pK, 3, 338 reactivity, 5, 627 synthesis, 5, 647 Imidazo[ 1,2-c]pyrimidines reactions, 5, 627 structure, 5, 610 synthesis, 5, 648-649 lmidazo[ 1,5-a]pyrimidines reactions, 5, 628 synthesis, 5, 649 lmidazo[l,5-6]pyrimidines synthesis, 5, 649-650 Imidazopyrrolopyridines bromination, 4, 506 lmidazo[4,5-6]quinoxaline nomenclature, 1, 22... 

Isothiazolo[3,4-d]pyridin-4(5H)-one, 3,6-dialkyl-applications, 6, 644 2H-Isothiazolo[2,3-a]pyrimidine synthesis, 6, 640 Isothiazolo[4,3-d]pyrimidine synthesis... 

H-Pyrrolo[3,2-d]pyrimidines synthesis, 3, 345 Pyrrolo[3,4-d]pyrimidines synthesis, 4, 524 Pyrrolopyrimidinones synthesis, 4, 518... 

Thieno[2,3-d]pyrimidine-6-catboxylic acid, 5-amino-synthesis, 4, 1019 Thienopyrimidines, 4, 1017-1022 Thieno[2,3-6]pyrimidines synthesis, 4, 748... 

The condensation of 1,3-dicarbonyl compounds 1 with amidines 2 catalyzed by acids or bases to give pyrimidine derivatives 3 is regarded as the Pinner pyrimidine synthesis. ... 

Although the Pinner pyrimidine synthesis was discovered a century ago only a few reports on the reaction mechanism have appeared. The condensation of acetylacetone, methyl acetoacetate, or dimethyl malonate with acetamidine (6) has been studied by Katritzky et al. and the reaction mechanisms for these processes have been proposed by these authors. Outlined below is the proposed mechanism of the condensation of methyl acetoacetate (4) with acetamidine (6)7... 

The active metabolite of leflunomide, the ring-opened drug A771726, inhibits dihydroorotate dehydrogenase (DHOD) which is the key enzyme of the de novo pyrimidine synthesis. Inhibition of synthesis stops proliferation of activated lymphocytes. The leflunomide derivative FK778 which shows similar therapeutic efficacy but shorter half-life is investigated in clinical trials. 

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