Physiological parameter

Data files on the THERdbASE CD are 1990 Bureau of Census Population Information, California Adult Activity Pattern Study (1987-88), AT T-sponsored National Activity Pattern Study (1985), Chemical Agents from Sources, Chemical Agent Properties, Air Exchange Rates, Information from EPA s TEAM (Total Exposure Assessment Methodology) Studies, Information from EPA s NOPES (NonOccupational Pesticides Exposure Study) Studies, Information from EPA s AIRS (Aerometric Information Retrieval System), and Human Physiological Parameters. 

Toxicity Test (Bioassay). Organisms representative of those to be protected are exposed to the test water under rigorously controlled conditions, usually in a laboratory environment. In this test the organisms, normally fish, are exposed for a standard time period in aquaria to various dilutions of waste or river water while some physiological parameter is carefully monitored to determine fish response. Behavior is also observed. 

At3g06550 - are deficient in wall-bound acetate. It would be interesting to test their resistance, lignin depositions and other physiological parameters under the influence of pathogens. It may be that these experiments will make clear the role of polysaccharide acetylation. 

A final, highly specialized procedure for monitoring carbon flow in plants involves the use of "CO . The use of this positron gamma-emitting isotope of C, with a half-life of 20.3 min, allowed several physiological parameters of my-corrhizal and non-mycorrhizal plants of Panicum coloratum to be measured simultaneously in real time (82). However, the technical problems associated with using "COi, particularly the ability to produce i.sotopes of carbon, and with handling this short half-life are likely to limit this approach to specialised facilities. 

Evaluate physiologic parameters that may influence pharmacokinetics. 

Sepsis is a continuum of physiologic stages characterized by infection, systemic inflammation, and hypoperfusion with widespread tissue injury.1 The American College of Chest Physicians and the Society of Critical Care Medicine developed definitions to utilize for sepsis (Table 79—l).2 They provide physiologic parameters categorizing patients as having bacteremia, infection, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple-organ-dysfunction syndrome (MODS).2 Standardized definitions have been developed for infections in critically ill patients.3... 

Deposition of inhaled gases and vapors is modeled as a partitioning process that depends on the physiological parameters noted above as well as the solubility and reactivity of a compound in the respiratory tract (see Figure 3-3). The ICRP (1994b) model defines three categories of solubility and reactivity SR-0, SR-1, and SR-2 ... 

RP Brown, MD Delp, SL Lindstedt, LR Rhomberg, RP Beliles. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol Ind Health 13 407-484, 1997. 

AD Arms, CC Travis. Reference Physiological Parameters in Pharmacokinetic Modeling. Washington, DC US Environmental Protection Agency, February 1988. 

The ability of ANNs to model nonlinear data is often crucial. Antoniewicz, Stephanopoulos, and Kelleher have studied the use of ANNs in the estimation of physiological parameters relevant to endocrinology and metabolism.9... 

Tab. 21.2. Physico-chemical and physiological parameters important to drug dissolution in the...

Factor Physico-chemical parameter Physiological parameter... 

In summary, it is emphasized that disease conditions may result in changed physiological parameters that could strongly influence the effectiveness of orally... 

Subsequently, individual data on exposure are converted to dose by using conversion factors (OECD/NEA, 1983). The choice of the appropriate numerical value depends on physiological parameters (e.g. respiratory minute volume) as well as physical characteristics of the inhaled aerosol (e.g. particle size). Mean values range typically from about 5 mSv/WLM (non-occupational exposure) to about 10 mSv/WLM (occupational exposure). 

Physical characteristics of the air inhaled (e.g. fraction of unattached Rn-d), ventilation of the room and physiological parameters (e.g. breathing rate) can influence significantly the exposure-dose conversion for the individual inhabitant, with the most frequently occurring value for indoor Rn-d exposure of about 5 mSv/WLM. 

Uncertainty factors An uncertainty factor of 10 was retained for interspecies variability to account for possible variability in arsine-induced hemolysis and progression to renal effects. An uncertainty factor for intraspecies variability of 3 was used, because the hemolytic response is likely to occur to a similar extent and with similar susceptibility in most individuals. This was based on the consideration that physiologic parameters (e.g., absorption, distribution, metabolism, structure of... 

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