Ferrocifen drugs

Zanellato I, Heldt J-M, Vessieres A, Jaouen G, Osella D (2009) Antiproliferative effect of ferrocifen drug candidates on malignant pleural mesothelioma cell lines. Inorg Chim Acta 362 4037 1042... 

Buriez, O., F. 1. Podvorica, A. Galtayries, E. Labbe, S. Top, A. Vessieres, G. Jaouen, C. Combellas, and C. Amatore. Surface grafting of a Jt-conjugated amino-ferrocifen drug. J. Electroanal. Chem. 699, 2013 21-27. 

The application of organometallic complexes of the other group 8 elements, iron and osmium, in anticancer drug design has until recently been almost exclusively focused on iron, with the ferrocenyl derivative of tamoxifen (ferrocifen) being the most prominent example (104). Organometallic osmium compounds have been little explored in this respect. 

Hillard EA, Vessieres A, Thouin L, Jaouen G, Amatore C (2006) Ferrocene-mediated proton-coupled electron transfer in a series of ferrocifen-type breast cancer drug candidates. Angew Chem Int Ed Engl 45 285-290... 

As shown in the case of the ferrocifens or the antimalarial drug candidate ferro-quine (Chapter 5), the additional activities gained with organometallic compounds can be used to circumvent resistances of piu-ely organic enzyme inhibitors, or even establish an inhibitory activity. 

ELECTROCHEMISTRY AND SUPRAMOLECULAR INTERACTIONS OF FERROCIFEN ANTICANCER DRUGS WITH CYCLODEXTRINS AND LIPID BILAYERS AN ELECTROCHEMICAL OVERVIEW... 

By analogy to the results obtained with the phenol ferrocifen derivatives, the cytotoxicity of compounds 10 and 11 may be ascribed to the intermediate formation of imino methides (Fig. 47.12). Actually, imino methides have been implicated in cytotoxic processes [35-40]. However, while acetylated quinone imines are important toxic compounds, namely, identified in the metabolism of Parkinson s disease drug tolcapone [41] and the analgesic acetaminophen [42], acetylated imine methides... 

In a similar study, ferrocene-substituted tamoxifens, ferrocifens, exhibited good antiproliferative effects on several breast cancer cell hnes." These ferrocifens are the first drugs that show good activity against both the hormone-dependent and hormone-independent breast cancer cells. 

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