Herpes simplex virus-1 thymidine

Herpes Simplex Virus-1 Thymidine Kinase Sodium Iodide Symporter Somatostatin Receptor Subtype 2 Dopamine-2 Receptor VI. Summary Acknowledgments References... 

Figure 8.10 (A) Relationship between the lung uptake of [ F]-FHBG and in vitro enzyme activity of a mutant HSVl-TK. Data are were combined from two studies and were fitted to a hyperbolic equation and corresponding regression curve and are displayed. (B) Relationship between the lung uptake of [ F]-FHBG and mutant HSVl-TK enzyme activity in rats with ANTU-induced increases in pulmonary vascular permeability. [1 F]-FHBG = 9-(4-[ F]-fluoro-3-hydroxymethylbutyl)guanine, ID = injected dose, mHSVl-TK = mutant Herpes simplex virus-1 thymidine kinase, PCV = penciclovir. [Reproduced with permission from Richard et al. (71).]...

Black ME, Kokoris MS, Sabo P. Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-medialed tumor cell killing. Cancer Res 2001 61(7) 3022-3026. 

Pelham, H.R.B. Bienz, M. (1982). A synthetic heat-shock promoter element confers heat-inducibility on the herpes simplex virus thymidine kinase gene. EM BO Journal, 1,1473-7. 

Figure 37-7. Transcription elements and binding factors in the herpes simplex virus thymidine kinase ffW gene. DNA-dependent RNA polymerase II binds to the region of the TATA box (which is bound by transcription factor TEND) to form a multicomponent preinitiation complex capable of initiating transcription at a single nucleotide (+1).The frequency of this event is increased by the presence of upstream c/s-acting elements (the GC and CAAT boxes). These elements bind frans-acting transcription factors, in this example Spl and CTF (also called C/EBP, NF1, NFY). These cis elements can function independently of orientation (arrows).

Hajri, A., Wack, S., Lehn, P., Vigneron, J.P. and Lehn, J.M. (2000) Efficient transfer of double suicide genes (herpes simplex virus-thymidine kinase and Escherichia coh-CD) into peritoneal disseminated pancreatic tumor cells by the cationic lipid BGTC. Cancer Gene Ther., 7,1393-1393. 

Goto, T., Nishi, T., Tamura, T., Dev, S.B., Takeshima, H., Kochi, M., Yoshizato, K., Kuratsu, J., Sakata, T., Hofmann, G.A. and Ushio, Y. (2000) Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene. Proc. Natl. Acad. Sci. USA, 97, 354-359. 

Vile, R.G. and Hart, I.R. (1993) Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA. Cancer Res., 53, 3860-3864. 

Fillat, C., Carrio, M., Cascante, A., and Sangro, B. Suicide gene therapy mediated by the herpes simplex virus thymidine kinase gene/ganciclovir system Fifteen years of application. Curr. Gene. Ther. 3 13-26, 2003. 

R. D. Alvarez, G. P. Siegal, J. T. Douglas, and D. T. Curiel, Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer, Clin. Cancer Res. 4 2455 (1998). 

A. Ido, K. Nakata, Y. Kato, K. Nakao, K. Murata, M. Fujita, N. Ishii, T. Tamaoki, H. Shiku, and S. Nagataki, Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter, Cancer Res. 55 3105 (1995). 

T. Osaki, Y. Tanio, I. Tachibana, S. Hosoe, T. Kumagai, I. Kawase, S. Oikawa, and T. Kishimoto, Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene, Cancer Res. 54 5258 (1994). 

T. Joki, M. Nakamura, and T. Ohno, Activation of the radiosensitive EGR-1 promoter induces expression of the herpes simplex virus thymidine kinase gene and sensitivity of human glioma cells to ganciclovir, Hum. Gene Ther. 6 1507 (1995). 

O. Wildner, R. M. Blaese, and J. C. Morris, Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase, Cancer Res. 59 410 (1999). 

D. Vandier, O. Rixe, M. Brenner, A. Gouyette, and F. Besnard, Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene, Cancer Res. 58 4577 (1998). 

Elshami, A. A., Kucharczuk, J. C., Zhang, H. B., Smythe, W. R., Hwang, H. C., Litzky, L. A., Kaiser, L. R. and Albelda, S. M. (1996). Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene. Hum. Gene Ther. 7, 141-148. 

Mizuno, M. et al. (1998). Adeno-associated virus vector containing the herpes simplex virus thymidine kinase gene causes complete regression of intrace-rebrally implanted human gliomas in mice, in conjunction with ganciclovir administration. Jpn. J. Cancer Res. 89(1), 76-80. 

Bilbao R, Gerolami R, Bralet MR et al. Transduction efficacy, antitumoral effect, and toxicity of adenovirus-mediated herpes simplex virus thymidine kinase/ ganciclovir therapy of hepatocellular carcinoma the woodchuck animal model. Cancer Gene Ther 2000 7(5) 657-662. 

In another study, the herpes simplex virus thymidine kinase (HSVtk) gene was evaluated as to its potency to increase the sensitization of ganciclovir (GCV) to glioma cell lines when that gene was incorporated in liposomes [407],... 

Haj-Ahmad Y, Graham FL. 1986. Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene. J. Virol. 57 267-74... 

Hattori Y, Maitani Y (2005) Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase. Cancer Gene Ther 12 796-809... 

In suicide gene therapy of solid tumors, the gene for Herpes simplex virus thymidine kinase is delivered to tumor cells and expressed, which in turn activates ganciclovir cytotoxicity. 

Tsuchiyama T, Kaneko S, Nakamoto Y, et al. (2003). Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase... 

Mizuguchi H, Hayakawa T (2002). Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase. Cancer Gene Ther. 9 236-242. 

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