Pleural neoplasms Mesothelioma

In rare instances, unusual substances have been demonstrated immunohistochemically in mesotheliomas. Okamoto and colleagues reported two neoplasms consistent with primary pleural mesotheliomas that contained anaplastic tumor giant cells that contained hCG, as demonstrated by immunohistochemistry. ... 

These neoplasms macroscopically look almost identical to pleural mesothelioma (Fig. 12.55). As reported by Koss and colleagues and in our experience,the majority of pseudomesotheliomatous lung neoplasms are adenocarcinomas, and the most common histologic subtype is what we refer to as a tubulodesmoplastic... 

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