Plasma using

Penetrante B M, Bardsley J N and Hsiao M C 1997 Kinetic analysis of non-thermal plasmas used for pollution control Japan. J. Appl. Phys. 36 5007-17... 

The low DOS achieved in i -Si H enables it to be readily doped, a prerequisite for any device appHcation n- and -type doping is achieved by the addition of PH and B2H to SiH in the gas phase, respectively. Figure 3, a plot of and conductivity activation energy, AH, as a function of PH and 2 6 content, shows that the most heavily f -type doping results in (Hem). By manipulating the plasma (using SiF and H2) or heavily diluting... 

DETERMINATION OF CLARITHROMYCIN IN HUMAN PLASMA USING RP-LC WITH ELECTROCHEMICAL DETECTION... 

Figure 11.5 Chromatograms of plasma samples obtained with fully automated on-line SPE-LC (a) dmg-ffee human plasma (b) human plasma spiked with omeprazole (100 ng/ml) and phenacetin (internal standard 1000 ng/ml). Reprinted from Journal of Pharmaceutical and Biomedical Analysis, 21, G. Garcia-Encina et al., Validation of an automated liquid chromatograpliic method for omeprazole in human plasma using on-line solid-phase exti action, pp. 371 - 382, copyright 1999, with permission from Elsevier Science.

Y. Oda, N. Asakawa, Y. Yoshida and T. Sato, On-line determination and resolution of the enantiomers of ketoprofen in plasma using coupled achiral-cliiral high-performance liquid chromatography , 7. Pharm. Biomed. Anal. 10 81-87 (1992). 

F. Silan, P. Jadaud, F. R. Whitheld and I. W. Wainer, Determination of low levels of the stereoisomers of leucovorin and 5-methylteti ahydrofolate in plasma using a coupled clii-ral-achiral liigh-performance liquid chromatograpliic system with post-cliiral column peak compression , 7. Chromatogr. 532 227-236 (1990). 

T. Okuda, Y. Nakagawa and M. Motohashi, Complete two-dimensional separation for analysis of acidic compounds in plasma using column-switching reversed-phase liquid clrromatography , 7. Chromatogr. B126 225-236 (1999). 

J. A. Pascual and J. Sanagustin, Eully automated analytical method for codeine quantification in human plasma using on-line solid-phase extraction and high-perfomance liquid clrromatogi aphy with ulti aviolet detection , 7. Chromatogr. B 724 295-302 (1999). 

This reaction was also used to deposit epitaxial silicon at the temperature range of 1000-1040°C, but the deposit was generally unsatisfactory and the reaction is no longer used for that purpose. However, if the reaction is enhanced with a plasma using electron cyclotron resonance (ECR), fluxes may be independently controlled and high-quality epitaxial silicon deposits are obtained at temperatures below 500°C.P 1... 

Determination of Gold, Cobalt, and Lithium in Blood Plasma Using the Mini-Massmann Carbon Rod Atomizer". Anal. Chem. (1974), 1445-1449. 

A typical OES spectrum taken from CH4-N2 plasma used in a-C(N) H film deposition is shown in Figure 13 [63]. This figure also shows band assignment of the... 

Restricted access phases are another approach to exploiting the differences in characteristics of analytes. Large analytes are excluded from an internal surface on which an adsorptive stationary phase is present. A herbicide analysis for Metsulfuron methyl, Bentazone, Bromoxynil, methylchlorophenoxy acid, and Mecoprop in the presence of humic acid was performed on restricted access reversed phase media.52 The cytostatic compound epirubicin and its metabolites were separated from plasma using a Pinkerton GFF II column.53 Gradient separations of polymers on reversed phase and on normal phase represent an alternative to gel permeation chromatography. Polyesters of noncrystalline materials were separated on a variety of such phases.54... 

Multiple electrodes have been used to obtain selectivity in electrochemical detection. An early example involved the separation of catecholamines from human plasma using a Vydac (The Separation Group Hesperia, CA) SCX cation exchange column eluted with phosphate-EDTA.61 A sensor array using metal oxide-modified surfaces was used with flow injection to analyze multicomponent mixtures of amino acids and sugars.62 An example of the selectivity provided by a multi-electrode system is shown in Figure 2.63... 

Dutton, J., Hodgkinson, A. J., Hutchinson, G., and Roberts, N. B., Evaluation of a new method for the analysis of free catecholamines in plasma using automated sample trace enrichment with dialysis and HPLC, Clin. Chem., 45, 394, 1999. 

Burke, R. A., Hvizd, M. G., and Shockley, T. R., Direct determination of polyglucose metabolites in plasma using anion-exchange chromatography with pulsed amperometric detection, ]. Chromatogr. B, 693, 353, 1997. 

Pachl, C., el al. (1995). Rapid and precise quantification of HTV-1 RNA in plasma using a branched DNA signal amplification assay. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 8,446-454. 

M Lui, JK Nicholson, JA Parkinson, JC Lindon. Measurement of bimolecular diffusion coefficients in blood plasma using two-dimensional 1II-1 II diffusion-edited total-correlation NMR spectroscopy. Anal Chem 69 1504-1509, 1997. 

He, J., Shibukawa, A., Nakagawa, T., Wada, H., Fujima, H., Imai, E., Go-oh, Y. (1993). Direct injection analysis of atenolol enantiomers in plasma using an achiral/chiral coupled column HPLC system. Chem. Pharm. Bull. 41, 544—548. 

Suckow, R.F., Zhang, M.F., Cooper, T.B. (1997). Enantiomeric determination of the phenyl-morphohnol metabolite of bupropion in human plasma using coupled achiral-chiral liquid chromatography. Biomed. Chromatogr. 11, 174-179. 

Kobylinska et al. [62] described a high performance liquid chromatographic analytical method for the determination of miconazole in human plasma using solid-phase extraction. The method uses a solid-phase extraction as the sample preparation step. The assay procedure is sensitive enough to measure concentrations of miconazole for 8 h in a pharmacokinetic study of Mikonazol tablets and Daktarin tablets in human volunteers. The pharmacokinetics of the two formulations was equivalent. 

Valproic acid was determined in tablets and plasma using ion-chromatography [29], The extract was injected onto a column (6.5 cm x 6 mm) of Dionex ICE separator resin fitted with a guard column of Aminex cation exchange resin and operated with aq. 0.5 mM C02 as mobile phase (0.7 mL/min) and conductivity detection. For tablets, the calibration graph was rectilinear for 0.2-25 pg/mL with limit of detection of 50 pg/mL. For plasma, the response was linear for 50-200 pg/mL and limit of detection was 2 pg/mL. 

L.-C. Chang, M.E. Meyerhoff, and V.C. Yang, Electrochemical assay of plasminogen activators in plasma using polyion-sensitive membrane electrode detection. Anal. Biochem. 276, 8-12 (1999). 

In 2003, Prior and others described methods for the extraction and analysis of hydrophilic and lipophilic antioxidants, using modifications of the ORAC procedure. These methods provide, for the first time, the ability to obtain a measure of total antioxidant capacity in the protein free plasma, using the same peroxyl radical generator for both lipophilic and hydrophilic antioxidants. This assay was also used to measure the total antioxidant capacity of guava fruit extracts (Thaipong and others 2006). 

Sample preparation — Analytes of interest were extracted from human plasma using the LLE technique. The following steps were followed ... 

The most common (off-line) sample preparation procedures after protein precipitation are solid phase extraction and liquid-liquid extraction. Multiple vendors and available chemistries utilize 96-well plates for solid phase extraction systems and liquid-liquid extraction procedures. Both extraction process can prepare samples for HPLC/MS/MS assay. Jemal et al.110 compared liquid-liquid extraction in a 96-well plate to semi-automated solid phase extraction in a 96-well plate for a carboxylic acid containing analyte in a human plasma matrix and reported that both clean-up procedures worked well. Yang et al.111 112 described two validated methods for compounds in plasma using semi-automated 96-well plate solid phase extraction procedures. Zimmer et al.113 compared solid phase extraction and liquid-liquid extraction to a turbulent flow chromatography clean-up for two test compounds in plasma all three clean-up approaches led to HPLC/MS/MS assays that met GLP requirements. 

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