Prediction of Plasma Concentration-Time Profile by Using the Wajima Allometric Method

1 Prediction of Plasma Concentration-Time Profile by Using the Wajima Allometric Method 

The Wajima aUometric method is used to extrapolate to human the plasma concentration-time profiles observed in vivo in each preclinical species (Wajima et al., 2003 VuppugaUa et al., 2011). Dose normaUzed curves are obtained by dividing the time axis with mean residence time (MRT set equals to V /CL) and the concentration axis with dose/V (CJ of the respective preclinical species. The plasma lime course in humans after IV administration can be simnlated using the normalized curve of the precUnical species and the predicted values of and CL in humans, hi other words, this 

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