Phenylmercuric acetate, with

Phenylmercuric acetate, with methallyl alcohol to yield 2-methyl-3-phenylpropion-aldehyde, 51, 17 1-PHENYL-1,3-PENTADIYNE, 50,... 

Phenyl isocyanate, with ethyl hydrazine-carboxylate to give 4-phenyl-l-car-bethoxysemicarbazide,51,122 Phenylmercuric acetate, with methallyl alcohol to yield 2-methyl-3-phenyl-propionaldehyde, 51, 17 1-PHENYL-1,3-PENTADIYNE, 50, 97 1-PHENYL-1,4-PENTADIYNE. 50, 97 a-Phenylpentanal, from 2-benzyl-4,4,6-trimethyl-5,6-dihydro-l,3(4H)-... 

The reaction of allylic alcohols and aryl halides in the presence of a palladium catalyst has been used in the past to prepare various 0-arylal-dehydes. The procedure described here is essentially that of Heck and Melpolder.3 A similar reaction has been carried out with bromobenzene and 2-methyl-2-propen-l-ol in hexamethylphosphoric triamide (HMPT) as solvent with sodium bicarbonate as base. A variety of other bases have also been used.4 2-Methyl-3-phenylpropanal has been prepared by reacting palladium acetate and phenylmercuric acetate with 2-methyl-2-propen-l-ol.5... 

Hill DB, Barnes AR. Compatibility of phenylmercuric acetate with cefuroxime and ceftazidime eye drops. Int J Pharm 1997 147 127-129. 

Collins AJ, Lingham P, Burbridge TA, Bain R. Incompatibility of phenylmercuric acetate with sodium metabisulphite in eye drop formulations. ] Pharm Pharmacol 1985 37(SuppL) 123P. 

Berlin M, Ullberg S. 1963. Accumulation and retention of mercury in the mouse Part II. An autoradiographic comparison of phenylmercuric acetate with inorganic mercury. Arch Environ Health 6 602-609. 

Derivation Reaction of phenylmercuric acetate with boric acid. 

Samples of natural water should either be analysed immediately or be stored (not for a very long time) at a decreased temperature to suppress microbial processes. For the determination of nitrate and nitrite it is useful to conserve the samples by addition of 1 ml chloroform or 0.1% phenylmercuric acetate per Utre. To prevent oxidation of sulphide and some other substances in water samples, reductants are added [5, 147]. If the distribution of a species between the f ree ionic form and various complexes is to be studied, as is of ten the case, care must be taken not to shift the equiUbrium by adding substances that would enter into side reactions with the studied species. 

In microwave plasma destmction, organic material is channeled through a plasma detector tube where destruction is initiated by microwave radiation-producing electrons. The electrons react with the organic molecules to form free radicals and final simple reaction products such as SO2, CO2, CO, H2O, HPO3, COCI2, and Br2 [60]. In bench-scale tests, the plasma method resulted in extensive detoxification (>99% destmction) for several pesticides, including malathion, phenylmercuric acetate (PMA), and Kepone [55]. 

Mercuration- Thallation. Mercuric acetate and thallium trifluoroacetate react with benzene to yield phenylmercuric acetate [62-38-4] or phenylthallic trifluoroacetate. The arylthallium compounds can be converted into phenols, nitriles, or aryl iodides (31). 

Heavy metals such as Ag+, Hg2+, or Pb2+, which form complexes with the -SH groups, also inactivate the enzyme. For example, the poison phenylmercuric acetate is a potent inhibitor of urease. 

CAUTION Phenylmercuric acetate is a poison. Do not touch the chemical with your hands. Do not swallow the solution. Wear rubber gloves in the preparation. 

The packaging material must not interact with the product either to adsorb substances from the product or to leach chemicals into the product. Plastics contain additives to enhance polymer performance. PVC may contain phthalate diester plasticizer, which can leach into infusion fluids from packaging. Antimicrobial preservatives such as phenylmercuric acetate are known to partition into rubbers and plastics during storage, thus reducing the formulation concentration below effective antimicrobial levels. 

When heated at 150° C. phenylmercuric acetate gives carbon, benzene, mercury, oxygen, and acetic anhydride. Dry distillation yields mercury, diphenyl oxide, and acetic anhydride. Distillation with sulphur gives mercury, benzene, acetic acid, acetic anhydride, and diphenyl sulphide. Boiling with dilute sulphuric or hydrochloric acid produces benzene, acetic acid, and a mercuric salt. The acetate is reduced by nascent hydrogen to benzene, mercury, and acetic acid. 

Fhenylmercuric thiosulphate. — Two molecules of phenylmercuric acetate in ammonium hydroxide—ammonium acetate solution are treated with one molecule of sodium thiosulphate, when a white precipitate is obtained, insoluble in ordinary solvents but dissolving in concentrated hydrochloric acid, with evolution of sulphur dioxide and deposition of sulphur. This thiosulphate readily dissolves in aqueous sodium thiosulphate, the solution giving mercury diphenyl on standing. The compound is not decomposed when heated to 200° C. 

The following derivatives are stable towards ammonium sulphide p - acetoxymercuri-o-nitroaniline, o - acetoxy mereuri-p-broniodimethyl-aniline, 2 4-diacetoxyniereuri-a-naphthylaniine, and p-dimethylamino-phenylmercuric acetate. If the latter compound be boiled with potassium iodide solution, then treated with hydrogen sulphide, only traces of mercuric sulphide are produced. Mercury compounds from jS-naphthylamine, j8-naphthylamine-C-sulphonic acid, 1 5-naphthyl amine sulphonic acid are decomposed b ammonium suli hide, wiiilst naphthi-onic acid derivatives are only slowty attacked. 

In Table 1.3.2 a method for the analysis of nitrates and nitrites for a wide variety of samples is given Aqueous nitrate ions are converted to nitrobenzene by reaction with benzene in the presence of concentrated sulfuric acid as catalyst. The special methods for the different materials are described. To stabilize samples against bacterial action, which can reduce nitrate concentrations, phenylmercuric acetate is added after collection ° Other inorganic compounds in the trace levels for gas-chromatographic determination are, for example, water and carbon monoxide, which were determined in organic solvents or air in the ppb-range ... 

Antimicrobial activity phenylmercuric acetate is a broad-spectrum antimicrobial preservative with slow bactericidal and fungicidal activity similar to phenylmercuric nitrate see Phenylmercuric Nitrate. 

Phenylmercuric acetate is reported to be incompatible with cefuroxime and ceftazidime. ... 

Phenylmercuric acetate is readily formed by heating benzene with mercuric acetate. 

Although phenylmercuric borate is an irritant, it has been reported to be less so than either phenylmercuric acetate or phenylmercuric nitrate. There is, however, some crosssensitization potential with other mercurial preservatives. 

Phenylmercuric nitrate is readily formed by heating benzene with mercuric acetate, and treating the resulting acetate with an alkali nitrate. 

Sodium alginate is incompatible with acridine derivatives, crystal violet, phenylmercuric acetate and nitrate, calcium salts, heavy metals, and ethanol in concentrations greater than 5%. Low concentrations of electrolytes cause an increase in viscosity but high electrolyte concentrations cause salting-out of sodium alginate salting-out occurs if more than 4% of sodium chloride is present. 

It is incompatible with phenylmercuric acetate when autoclaved in eye drop preparations. ... 

Toxic effects of phenylmercuric acetate are correlated with its rapid metabolic breakdown into the mercuric ion. Generally, mercury interferes with cellular enzymatic mechanisms by combining with sulfhydryl (-SH) groups of different enzymes and thereby produces nonspecific cell injury or death. 

Phenylmercuric acetate can be lethal with oral doses as low as 100 mg. The principal manifestations of mercury salt poisoning are gastrointestinal, hepatic, and renal damage. 

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