Ovarian tumors Wilms’ tumor

Doxorubicin (Adriamycin, Rubex) [Antineoplastic/ Anthrocycline Antibiotic] Uses Acute leukemias Hodgkin Dz NHLs soft tissue, osteo Ewing sarcoma Wilms tumor neuroblastoma bladder, breast, ovarian, gastric, thyroid, lung CA Action Intercalates DNA X DNA topoisomerases I II Dose 60-75 mg/m q3wk X w/ hqjatic impair IV use only X... [Pg.140]

Wilms tumor, Ewing s sarcoma, rhabdomyosarcoma, gestational choriocarcinoma, testicular tumors, lymphomas, melanomas Breast, ovarian, endometrial, bladder, thyroid cancers oat cell cancer of the lung Testicular, ovarian germ cell cancers, small-cell lung cancer, acute myelogenous and lymphoblastic leukemia... [Pg.654]

Unlabeled Uses Adrenocortical, bladder, cervical, endometrial, prostatic, testicular carcinomas Ewing s sarcoma multiple sclerosis non-small cell, small cell lung cancer organ transplant rejection osteosarcoma ovarian germ cell, primary brain, trophoblastic tumors rheumatoid arthritis soft tissue sarcomas systemic dermato-myositis systemic lupus erythematosus Wilms tumor... [Pg.314]

Cyclophosphamide Same as above Breast cancer, ovarian cancer, non-Flodgkin s lymphoma, CLL, soft tissue sarcoma, neuroblastoma, Wilms tumor, rhabdomyosarcoma Nausea and vomiting ... [Pg.1168]

Doxorubicin Oxygen free radicals bind to DNA causing single- and double-strand DNA breaks inhibits topoisomerase II intercalates into DNA Breast cancer, Hodgkin s and non-Hodgkin s lymphoma, soft tissue sarcoma, ovarian cancer, non-small cell and small cell lung cancer, thyroid cancer, Wilms tumor, neuroblastoma Nausea, red urine (not hematuria) Cardiotoxicity (see text), alopecia, myelosuppression, stomatitis... [Pg.1176]

Clinical uses Leukemia, lymphoma, multiple myeloma, sarcomas, germ cell tumors of ovaries or testes, head and neck cancer, lung cancer, Wilms tumor, breast cancer, stomach cancer, pancreatic cancer, liver cancer, ovarian cancer, bladder cancer, uterine cancer, neuroblastoma. [Pg.142]

Doxorubicin (Adriamycin, Adria, Doxo, hydroxydaunorubicin) -Liposomal doxorubicin (Doxil) Breast cancer osteosarcoma and soft tissue sarcomas NHL HD ALL ANLL bladder cancer ovarian cancer thyroid cancer Wilms tumor neuroblastoma SCLC KS (liposomal) gastric cancer multiple myeloma NSCLC endometrial cancer... [Pg.2303]

Shimizu M, Toki T, Takagi Y, et al. Immunohistochemical detection of the Wilms tumor gene (WTl) in epithelial ovarian tumors. Int J Gynecol Pathol. 2000 19 158-163. [Pg.251]

Waldstrom M, Grove A. Immunohistochemical expression of wilms tumor gene protein in different histologic subtypes of ovarian carcinomas. Arch Pathol Lab Med. 2005 129 85-88. [Pg.251]

Hwang H, Quermeville L, Yaziji H, et al. Wilms tumor gene product Sensitive and contextually specific marker of serous carcinoma of ovarian surface epithelial origin. Appl Immunohistochem Mol Morphol. 2004 12 122-126. [Pg.462]

Wilms tumor gene product (WTl) has been established as a good marker for mesothelial cells. Studies have also demonstrated that WTl is a highly sensitive and specific marker of serous carcinomas of ovarian surface epithelial origin (both ovarian and extra-ovarian). Mucinous and micropapillary breast carcinomas may express WTl and thus confound the distinction between breast carcinoma and metastatic ovarian serous carcinoma (Fig. 21.13). ° ... [Pg.906]

Same as etoposide acute lymphoblastic leukemia in children Ovarian cancer small-cell lung cancer colon and lung cancer Choriocarcinoma Wilms tumor rhabdomyosarcoma testis Kaposi s sarcoma... [Pg.855]

Wilms tumor protein-1 (WT-1) Nephroblastoma, mesothelioma, metanephric adenoma, ovarian serous carcinoma AML, desmoplastic small round cell tumor, endometrial stromal sarcoma, uterine leiomyosarcoma, granulosa cell tumor, thecoma, rhabdoid tumor Kidney, mesothelial cells, granulosa cells, Sertoli cells, fallopian tube endometrial stroma, spleen... [Pg.72]

It is indicated in GI tract carcinoma, acute myeloblastic leukaemia, bronchogenic, breast and ovarian carcinoma, soft tissue and bone sarcomas, malignant lymphoma primary management of nonmetastatic bladder carcinoma (intravesical administration), Wilm s tumor and neuroblastoma. [Pg.375]

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