Neuroblastoma, SCLC

Doxorubicin (Adriamycin, Adria, Doxo, hydroxydaunorubicin) -Liposomal doxorubicin (Doxil) Breast cancer osteosarcoma and soft tissue sarcomas NHL HD ALL ANLL bladder cancer ovarian cancer thyroid cancer Wilms tumor neuroblastoma SCLC KS (liposomal) gastric cancer multiple myeloma NSCLC endometrial cancer... [Pg.2303]

Tumor overexpression E.g., HNSCC, breast cancer E.g., neuroblastomas, SCLC ... [Pg.99]

Vincristine (VCR, Oncovin) ALL HD NHL multiple myeloma breast cancer SCLC, KS brain tumors soft tissue sarcomas osteosarcomas neuroblastoma Wilms tumor... [Pg.1409]

CCK receptors SCLC, pancreatic cancers, neuroblastomas, meningiomas, medullary thyroid carcinomas... [Pg.267]

Opioid receptors SCLC, neuroblastomas, breast tumors, thymomas... [Pg.267]

Many SCLC patients mount an antitumor immune response without signs of PNS [9, 167, 174]. Nevertheless, most SCLC patients do not have this immune response. Thus, the rarity of PNS cannot be attributed to infrequency of antigen expression. This discrepancy suggests that additional factors, perhaps related to tumor major histocompatibility complex (MHC) expression, contribute to the initiation of the PNS immune response. A study of Hu antigen and MHC class I expression in SCLC and neuroblastoma supports this theory. Seventeen of 20 tumors from Hu antibody positive patients expressed both proteins, but only 4 of 30 specimens from seronegative individuals expressed both proteins [171]. Altered expression and/or down-regulation of MHC molecules is a common immune-evasive strategy of tumor cells [175],... [Pg.165]

Enolase is a glycolytic enzyme also known as phosphopyru-vate hydratase. Neuron-specific enolase (NSE) is the form of enolase found in neuronal tissue and in the cells of the diffuse neuroendocrine system and the amine precursor uptake, and decarboxylation (APUD) tissue. NSE is found in tumors associated with the neuroendocrine origin, including small cell lung cancer (SCLC), neuroblastoma, pheochromocytoma, carcinoid, medullary carcinoma of the thyroid, melanoma, and pancreatic endocrine tumors. [Pg.756]

Cyclophosphamide (Cytoxan) Breast cancer NHL ALL ANLL CLL ovarian cancer myeloma retinoblastoma neuroblastoma HD NSCLC SCLC endometrial cancer soft-tissue sarcomas BMT-preparative (high-dose) bladder cancer SLE autoimmune disorders... [Pg.2307]

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