Olfaction neurons

C. Zekno and N. Sobel, Humans as an animal model for systems-level organization of olfaction , Neuron 48 (2005) 431-454. 

Larsson MC, Domingos AI, Jones WD, Chiappe ME, Amrein H, Vosshall LB (2004) Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction. Neuron 43 703-714... 

Kwon JY, Dahanukar A, Weiss LA, Carlson JR (2007) The molecular basis of C02 reception in Drosophila. Proc Natl Acad Sci USA 104 3574-3578 Laissue PP, Reiter C, Hiesinger PR, Halter S, Fischbach KF, Stocker RF (1999) Three-dimensional reconstruction of the antennal lobe in Drosophila melanogaster. J Comp Neurol 405 543-552 Larsson MC, Domingos AI, Jones WD, Chiappe ME, Amrein H, Vosshall LB (2004) Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction. Neuron 43 703-714 Lacaille F, Hiroi M, Twele R, Inoshita T, Umemoto D, Maniere G, Marion-Poll F, Ozaki M, Francke W, Everaerts C, Tanimura T, Ferveur J-F (2007) A inhibitory sex pheromone tastes bitter for males. PLoS ONE 2 e661 Laurent G (1996) Odor images and tunes. Neuron 16 473-476... 

Brody, C., Hopfield, J.J. Simple networks for spike timing computation and olfaction. Neuron. 37, 843-852 (2003)... 

The oscillation of membrane current or membrane potential is well-known to occur in biomembranes of neurons and heart cells, and a great number of experimental and theoretical studies on oscillations in biomembranes as well as artificial membranes [1,2] have been carried out from the viewpoint of their biological importance. The oscillation in the membrane system is also related to the sensing and signal transmission of taste and olfaction. Artificial oscillation systems with high sensitivity and selectivity have been pursued in order to develop new sensors [3-8]. 

Meredith M. (1982). Stimulus access and other processes involved in nasal chemosensory function potential substrates for neuronal and hormonal influence. In Olfaction and Endocrine Regulation (Breipohl W., ed.). IRL Press, London, pp. 223-248. 

Keywords action potential axon ion channel mechanoreceptor membrane potential neurons neurotransmitter olfaction proteins synaptic gap. 

In vertebrates the neurons for olfaction are located in the nose mucosa and consist of short neurons with a peripheral ending endowed with odorant receptors for a large number of molecules in the environment. Each receptor neuron only contains one odorant receptor and is connected directly with the olfactory lobe of the brain. The vertebrate olfactory system must cope with a staggering developmental problem how to connect millions of olfactory neurons expressing different odorant receptors to appropriate targets in the brain. 

Dpving, K. B., Westerberg, H., and Johnsen, P. B. (1985). Role of olfaction in the behavior and neuronal responses of Atlantic salmon, Salmo salar, to hydrographic stratification. Caradian Journal of Fisheries and Aquatic Science 42,1658-1667. 

Kosbash He has talked to me about this, and they have just completed an Affymetrix gene array experiment with Gonjaulax, and there is lots of circadian transcriptional regulation. I presume that they concentrated on translation all these years because that is where their original work led them. Paul Hardin, is there enough known for you to use a driver in a neuron which deals with another odorant to show that the rhythms are relevant for olfaction ... 

The detection of light, smells, and tastes (vision, olfaction, and gustation, respectively) in animals is accomplished by specialized sensory neurons that use signal-transduction mechanisms fundamentally similar to those that detect hormones, neurotransmitters, and growth... 

A primary function of the nasal cavity is olfaction. The location of the olfactory mucosa, recessed on the roof of the respiratory passage, means that it is accessed only by diffusion of volatile or airborne substances in inhaled air. The specialized epithelium features sensitive olfactory neurons that provide a direct link to the CNS. The structural features of the epithelium and potential for drug delivery are considered in detail in Section 19.6.1. 

Derby, C. D., Single unit electrophysiological recordings from crustacean chemoreceptor neurons, in Experimental Biology of Taste and Olfaction Current Techniques and Protocols, Spielman, A. I. and Brand, J. G., Eds., CRC Press, Boca Raton, FL, 1995, 241. 

Vosshall L. B. and Young M. W. (1995) Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells. Neuron 15, 345-360. WarrC. G., Clyne P. J., de BruyneM., Kim J., Carlson J. R. (2001) Olfaction in Drosophila coding, genetics and e-genetics. Chem. Senses 26, 201-206. 

The sensitivity and selectivity of olfaction and contact chemosensation are due (1) in the brain, to the existence of a neuronal network of neurons tuned to a specific chemical stimulus, and (2) in the periphery, to the existence of olfactory/ chemosensory receptor neurons housed in sensory microorgans called sensilla. The sensilla can best be viewed as simple cuticular porous extrusions that increase the surface that captures airborne odorants or chemicals dissolved in water droplets. They contain the receptive olfactory or chemosensory structures (Schneider, 1969). The olfactory sensilla are most numerous on the antennae and mediate the reception of sex pheromones and plant volatiles, as well as other odorants. Low volatility pheromones may also be detected by contact chemoreceptors on... 

A role for DOR genes in olfaction requires that they are expressed in OSNs, where they can interact with odors and transmit odor-activated neuronal activity. To address this question Clyne et al. (1999) used reverse transcription-PCR (RT-... 

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