Heart cells

L-lactate dehydrogenase semm differentiation of heart cell damage... 

Cobbold, P. H., and Bourne, P. K. (1984). Aequorin measurement of free calcium in single heart cells. Nature 312 444-446. 

Cellular therapies in transplantation and cancer are based on specific cells separated or sorted from human blood, bone marrow, or cord blood by means of their specific cell surface markers or cell differentiation antigens, e.g., CD3, CD4, CD8, CD 14, CD 19, and CD34. For example, the CD34+ stem cells, especially those derived from human embryos, have the capacity to differentiate in culture to generate different somatic cells, e.g., liver cells, heart cells, neurons, etc. This exploding field of research is now termed regenerative medicine. 

Purely electrical models of the heart are only a start. Combined electromechanical finite-element models of the heart take into account the close relationship that exists between the electrical and mechanical properties of individual heart cells. The mechanical operation of the heart is also influenced by the fluid-structure interactions between the blood and the blood vessels, heart walls, and valves. All of these interactions would need to be included in a complete description of heart contraction. 

Neither L nor T channels appear susceptible to the form of G-protein-mediated inhibition characteristic of N or P/Q channels. However, as in the heart cells, L-type Ca +... 

Gadsby, D.C., Kimura, J. and Noma, A. (1985). Voltage dependence of Na/K pump current is isolated heart cells. Nature 315, 63-65. 

Lee, K.S., Marban, E. and Tsien, R.W. (1985). Inactivation of calcium channels in mammalian heart cells joint dependence on membrane potential and intracellular calcium. J. Physiol. 364, 395-411. 

The oscillation of membrane current or membrane potential is well-known to occur in biomembranes of neurons and heart cells, and a great number of experimental and theoretical studies on oscillations in biomembranes as well as artificial membranes [1,2] have been carried out from the viewpoint of their biological importance. The oscillation in the membrane system is also related to the sensing and signal transmission of taste and olfaction. Artificial oscillation systems with high sensitivity and selectivity have been pursued in order to develop new sensors [3-8]. 

W Gevers. (1977). Generation of protons by metabolic processes in heart cells. J Mol Cardiol 9 867-874. 

Marx SO, Reiken S, Hisamatsu Y et al 2000 PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor) defective regulation in failing hearts. Cell 101 365-376... 

Mehorta and coworkers (1989) observed that isolated fractions of brain and heart cells from rats orally administered 0.5-10 mg endrin/kg showed significant inhibition of Ca+2 pump activity and decreased levels of calmodulin, indicating disruption of membrane Ca+2 transport mechanisms exogenous addition of calmodulin restored Ca+2-ATPase activity. In vitro exposure of rat brain synaptosomes and heart sarcoplasmic reticuli decreased total and calmodulin-stimulated calcium ATPase activity with greater inhibition in brain preparations (Mehorta et al. 1989). However, endrin showed no inhibitory effects on the calmodulin-sensitive calcium ATPase activity when incubated with human erythrocyte membranes (Janik and Wolf 1992). In vitro exposure of rat brain synaptosomes to endrin had no effect on the activities of adenylate cyclase or 3, 5 -cyclic phosphodiesterase, two enzymes associated with synaptic cyclic AMP metabolism (Kodavanti et al. 1988). 

Propranolol slows heart rate, increases the effective refractory period of atrioventricular ganglia, suppresses automatism of heart cells, and reduces excitability and contractibihty of the myocardium. It is used for supraventricular and ventricular arrhythmias. Synonyms of this drug are anaprilin, detensiel, inderal, novapranol, and others. 

I. Hellgren, A. Mustafa, M. Riazi, I. Suliman, C. Sylven, A. Adem, Muscarinic M3 receptor subtype gene expression in the human heart. Cell Mol. Life Sci. 57 (2000) 175-180. 

Tunicamycin and 2-deoxy-D-arahino-hexose interfere with the expression of lipase (glycerol-ester hydrolase, EC 3.1.1.3) in cultured, mesenchymal rat-heart cells. The causes of inhibition were not inves-... 

Gap junction conductance (gj) of neonatal rat heart cells varies with temperature (37 °C, 48.3 nS 14 °C, 21.4 nS -2°C, 17.5 nS) [Bukauskas and Weingart, 1993] so that gj has been assumed to be at least in part enzymatically controlled. Several protein kinases are known to be involved in the regulation of the gap junction channels. However, the situation is rather complicated since the same protein kinase may enhance or reduce gap junctional conductance in different tissues or in different species. Thus, generalizations should be avoided and the specific condition has to be taken into account. One of the first to be described was protein kinase A (PKA), the cAMP-dependent protein kinase, which can enhance junctional conductance in hepatocytes coupled via Cx32 and Cx26 [Saez et al., 1986, 1990]. Similarly, an increase in junctional conduc-... 

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