Myeloid leukemias

Enzymes Degrading Macromolecules. Enzymes that degrade macromolecules such as membrane polysaccharides, stmctural and functional proteins, or nucleic acids, have all shown oncolytic activity. Treatment strategies include the treatment of inoperable tumors with pepsin (1) antitumor activity of carboxypeptidase (44) cytotoxicity of ribonudease (45—47) oncolytic activity of neuraminidase (48—52) therapy with neuraminidase of patients with acute myeloid leukemia (53) antitumor activity of proteases (54) and hyaluronidase treatment in the management of human soHd tumors (55). [Pg.308]

Busulfan was used for the treatment of chronic myeloid leukemia and polycytemia vera. [Pg.55]

Moore J, Seiter K, Kolitz J et al (2006) A Phase II study of Bcl-2 antisense (oblimersen sodium) combined with gemtuzumab ozogamicin in older patients with acute myeloid leukemia in first relapse. Leuk Res 30(7) 777-783... [Pg.188]

Inhibition of hematopoietic growth factors Imatinib (Glivec ) is applied to treat chronic myeloid leukemia in Philadelphia-chromosome positive patients. In these patients, translocation of parts of chromosomes 9 and 22 results in the expression of a fusion protein with increased tyrosine kinase activity, called Bcr-Abl. Imatinib is a small Mw inhibitor selective for the tyrosine kinase activity of Bcr-Abl. Thereby, it inhibits the Bcr-Abl induced cell cycle progression and the uncontrolled proliferation of tumor cells. [Pg.411]

Seggewiss R, Pittaluga S, Adler RL, Guenaga FJ, Ferguson C, Pilz I, Ryu B, Sorrentino BP, Young WS, Donahue RE, von Kalle C, Nienhuis AW, Dunbar CE (2006) Acute myeloid leukemia associated with retroviral gene transfer to hematopoietic progenitor cells of a rhesus macaque. Blood 107 3865-3867... [Pg.296]

Raponi M, Belly RT, Karp JE, Lancet JE, Atkins D, Wang Y. Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia. BMC Cancer 2004 4 56. [Pg.161]

Term to UltraLink myeloblastic leukemia Concept Type DISEASE Normalized term myeloid leukemia Synonyms ... [Pg.741]

Acute myeloid leukemia CD13, CD15, CD33, CD14, CD64, and C-KIT... [Pg.1401]

Gregory J, Arced R. Acute myeloid leukemia in children A review of risk factors and recent trials. Cancer Invest 2002 20 1027-1037. [Pg.1413]

Ishii E, Kawasaki H, Isoyama K, et al. Recent advances in the treatment of infant acute myeloid leukemia. Leukemia Lymphoma 2003 44 741-748. [Pg.1413]

Deininger MWN, O Brien SG, Ford JM, Druker BJ. Practical management of patients with chronic myeloid leukemia receiving imatinib. J Clin Oncol 2003 21 1637-1647. [Pg.1424]

Cancers Multiple myeloma Non-Hodgkin s lymphoma Hodgkin s disease Acute myeloid leukemia Neuroblastoma Germ cell tumors Acute myeloid leukemia Acute lymphoblastic leukemia Chronic myeloid leukemia Myelodysplastic syndrome Myeloproliferative disorders Non-Hodgkin s lymphoma Hodgkin s disease Chronic lymphocytic leukemia Multiple myeloma... [Pg.1448]

GCSF, granulocyte colony stimulating factor GMCSF, granulocyte-macrophage colony stimulating factor SQ, subcutaneous IV, intravenous AML, acute myeloid leukemia. [Pg.1471]

HT is a 55-year-old man with newly diagnosed acute myeloid leukemia. The patient is asymptomatic at this time. Laboratory results reveal the following significant findings ... [Pg.1486]

Acute myeloid leukemia (especially white blood cell count greater than 50/mm3)... [Pg.1486]

American Conference of Governmental Industrial Hygienists Absorption, Distribution, Metabolism, and Excretion acute myeloid leukemia atmosphere... [Pg.173]

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