Acute myeloid leukemia prognosis

Christiansen DH, Andersen MK, Pedersen-Bjergaard J. Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis. J Clin Oncol 2001 19 1405-13. 

Genetics has already been incorporated into the care of children with cancer an example is the Philadelphia Chromosome, a chromosomal anomaly produced as a result of reciprocal translocation between chromosomes 9 and 22 [t(9 22)(q34 qll)] that is most commonly seen as a marker of chronic myeloid leukemia [50]. The presence of this chromosomal anomaly is associated with altered prognosis—and the need for different therapy—when seen in the context of acute lymphoblastic leukemia in childhood [51], An area of oncology care where genetics has not been widely used has been in the evaluation—and possibly prevention—of adverse drug reactions [52],... 

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