Acute myeloid leukemia cell proliferation

Estrov Z, Shishodia S, Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M, Aggarwal BB. 2003. Resveratrol blocks interleukin-1 beta-induced activation of the nuclear transcription factor NF-kB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 102 987-995. 

Although reversible increases in circulating blasts during GM-CSF treatment are sometimes noted and have raised concern on the possible accelerated occurrence of acute leukemia, the progression of myelodysplastic syndromes to acute myeloid leukemia has been only anecdotally reported (SEDA-19, 342) (57). There was no evidence of significant leukemic cell proliferation in patients with acute myeloid leukemia, and no increased... 

Acute myeloid leukemia (AM L) is a neoplastic proliferation of myeloid hematopoietic stem cells or myeloid precursors including myeloblasts, monoblasts, erythroblasts and megakaryoblasts. According to the FAB classification, AML is classified into eight subtypes (M0-M7) depending on the cell type involved in the neoplastic process. 

Park et al. (1971) compared the effects of ascorbate on mouse plasmacytoma cells with that on normal bone marrow cells forming granulocytic colonies. Only the plasmacytoma cells responded with marked proliferation. This, however, does not imply that myeloic stem cells in general are unresponsive to ascorbate. The growth of the human promyeloic tumor cell line HL-60 was stimulated by ascorbate (Alcain et al., 1990). Similarly, bone marrow cells from a variety of acute myeloid leukemia patients responded with growth, or growth inhibition or remained unaffected (Park et al, 1992). In this context it should be stressed that inhibition of... 

These data indicate that the biochemical heterogeneity within the spectrum of lymphoid proliferation is identical in the self limiting proliferation in IM (table 1) and in T-cell acute lymphoid leukemia (2). Myeloid proliferation differs from these lymphoid proliferations in the normal PNP activity (table 1). 

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