Acute myeloid leukemia evaluation

Genetics has already been incorporated into the care of children with cancer an example is the Philadelphia Chromosome, a chromosomal anomaly produced as a result of reciprocal translocation between chromosomes 9 and 22 [t(9 22)(q34 qll)] that is most commonly seen as a marker of chronic myeloid leukemia [50]. The presence of this chromosomal anomaly is associated with altered prognosis—and the need for different therapy—when seen in the context of acute lymphoblastic leukemia in childhood [51], An area of oncology care where genetics has not been widely used has been in the evaluation—and possibly prevention—of adverse drug reactions [52],... 

Common signs and symptoms at presentation are described in the clinical presentation boxes. In addition to clinical presentation, laboratory and pathology evaluations are required for a definitive diagnosis of leukemia. The most important test is a bone marrow biopsy and aspirate, which is submitted to hematopathology for numerous evaluations. Cytochemical stains are helpful to determine if the acute leukemia is of myeloid or lymphoid lineage. Immunophe-... 

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