In myeloid leukemia

Jaffrezou, . P., Bettaieb, A., Levade, T., and Laurent, G., 1998, Antitumor agent-induced apoptosis in myeloid leukemia cells a controlled suicide. Leukemia Lymphoma 29 453-463... 

Wang ZG, Rivi R, Delva L et al (1998) Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner. Blood 92 1497-1504... 

Mehta K and Cheema S (1999) Retinoid-mediated signaling pathways in CD38 antigen expression in myeloid leukemia cells. Leukemia and Lymphoma 32,441-9. 

SIN-1 induced higher antiproliferation activity in BCR-ABL+ leukemia K562 cells when compared to normal hemopoietic cells [52]. NO-mediated apoptosis is shown to be inhibited in myeloid leukemia cells by the elevation of intracellular iron. 

Also relevant in this context is the observation by Jaffrezou et al. [120] that ceramide enhances neutral sphingomyelinase activity in myeloid leukemia cells and in normal skin fibroblasts. However, these results were obtained with short-chain, cell-permeant ceramides, whose physical effects on membranes may differ from the more frequent long-chain ones [9]. The subject is interesting enough to deserve a more detailed investigation. 

Moskow, J.J., Bullrich, F., Huebner, K., Daar, I.O., Buchberg, A.M. 1995. Meisl, a PBXl-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol. Cell Biol. 15, 5434-5443. 

Pronounced changes of arylsulfohydrolases have been observed in many pathological states. Many diseases are associated with increased excretion of arylsulfohydrolases in urine. A 30-fold increase of arylsulfohydrolase activity is observed in myeloid leukemia. Rather substantial increases in sulfohydrolases are also noticed in diseases of the bladder, testes, and uterus and in cancer of the breast and the prostate gland (Dzialozynski and Gniot-Szulzycka, 1967 Posey and Morgan, 1977 Peltonen et al., 1981). 

Hoffman-Liebermann, B. and Liebermann, D.A. (1991a) Suppression of c-myc and c-myb is tightly linked to terminal differentiation induced by lL-6 or LIF and not growth inhibition in myeloid leukemia cells. Oncogene 6 903-909. 

Sachs L (1982) Normal development programms in myeloid leukemia Regulatory proteins in the control of growth and differentiation. Cancer Surveys 1 321-342... 

Matikainen S, Serkkola E, Hurme M (1991) Retinoic acid enhances IL-ip expression in myeloid leukemia cells and in human monocytes. J Immunol 147 162-167... 

Matikainen S, Ronni T, Lehtonen A, Sareneva T, Melen K, Nordling S, Levy DE, Julkunen I (1997) Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons. Cell Growth Differ 8 687-698... 

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