Acute myeloid leukemia clinical presentation

The term leukemia was coined by Virchow to describe the white blood of some patients that he saw under the microscope in 1845. Historically, leukemia has been classified as acute or chronic based on differences in cell of origin and cell line maturation, clinical presentation, rapidity of progression of the untreated disease, and response to therapy. Four major leukemias are recognized acute lymphocytic (or lymphoblastic) leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid... 

Common signs and symptoms at presentation are described in the clinical presentation boxes. In addition to clinical presentation, laboratory and pathology evaluations are required for a definitive diagnosis of leukemia. The most important test is a bone marrow biopsy and aspirate, which is submitted to hematopathology for numerous evaluations. Cytochemical stains are helpful to determine if the acute leukemia is of myeloid or lymphoid lineage. Immunophe-... 

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