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Chronic lymphocytic leukemias

O Brien S, Moore JO, Boyd TE et al (2007) Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. J Clin Oncol 25(9) 1114-1120... [Pg.188]

This is a humanized anti-CD52 monoclonal antibody. At present it is in clinical use after bone marrow transplantation and for the treatment of refractory chronic lymphocytic leukemia. [Pg.619]

Alemtuzumab is the antibody to the CD52 receptor present on B and T lymphocytes. The pharmacokinetics of alemtuzumab demonstrate a terminal half-life of 7 days. Alemtuzumab has shown clinical activity in the treatment of chronic lymphocytic leukemia. Severe and prolonged (6 months) immunosuppression may result, which necessitates prophylaxis with cotrimox-azole and antivirals to prevent opportunistic infections. [Pg.1294]

Precursor B-cell neoplasm Precursor B-lymphoblastic leukemia/lymphoma Mature (peripheral) B-cell neoplasms B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma... [Pg.1374]

Describe the clinical course of chronic lymphocytic leukemia (CLL). [Pg.1415]

Describe patients who may be observed without treatment and those who receive aggressive treatment for chronic lymphocytic leukemia (CLL). [Pg.1415]

Chronic lymphocytic leukemia (CLL) patients who receive fludarabine-based combination chemotherapy and rituximab may have long-term disease-free survival. [Pg.1415]

Cancers Multiple myeloma Non-Hodgkin s lymphoma Hodgkin s disease Acute myeloid leukemia Neuroblastoma Germ cell tumors Acute myeloid leukemia Acute lymphoblastic leukemia Chronic myeloid leukemia Myelodysplastic syndrome Myeloproliferative disorders Non-Hodgkin s lymphoma Hodgkin s disease Chronic lymphocytic leukemia Multiple myeloma... [Pg.1448]

Chronic lymphocytic leukemia (especially bulky lymphadenopathy)... [Pg.1486]

CLL Chronic lymphocytic leukemia DTR Deep-tendon reflex... [Pg.1554]

ZAP-70 expression An intracellular tyrosine kinase found in B cells in chronic lymphocytic leukemia. [Pg.1579]

Jones D, Benjamin RJ, Shahsafaei A, Dorfman DM. The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia. Blood 2000 95 627-632. [Pg.346]

Till KJ, Lin K, Zuzel M, Cawley JC. The chemokine receptor CCR7 and a4 inte-grin are important for migration of chronic lymphocytic leukemia cells into lymph nodes. Neoplasia 2002 99 2977-2984. [Pg.347]


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B-cell chronic lymphocytic leukemia

Chronic lymphocytic leukemia Alemtuzumab

Chronic lymphocytic leukemia Rituximab

Chronic lymphocytic leukemia case study

Chronic lymphocytic leukemia chemotherapy

Chronic lymphocytic leukemia clinical presentation

Chronic lymphocytic leukemia diagnosis

Chronic lymphocytic leukemia evaluation

Chronic lymphocytic leukemia monoclonal antibodies

Chronic lymphocytic leukemia prognosis

Chronic lymphocytic leukemia staging

Chronic lymphocytic leukemia treatment

Chronic lymphocytic leukemia/small

Leukemia chronic

Lymphocyte leukemia

Lymphocytic leukemia

Lymphomas chronic lymphocytic leukemia/small

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