Chronic lymphocytic leukemias

O Brien S, Moore JO, Boyd TE et al (2007) Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. J Clin Oncol 25(9) 1114-1120... [Pg.188]

This is a humanized anti-CD52 monoclonal antibody. At present it is in clinical use after bone marrow transplantation and for the treatment of refractory chronic lymphocytic leukemia. [Pg.619]

Alemtuzumab is the antibody to the CD52 receptor present on B and T lymphocytes. The pharmacokinetics of alemtuzumab demonstrate a terminal half-life of 7 days. Alemtuzumab has shown clinical activity in the treatment of chronic lymphocytic leukemia. Severe and prolonged (6 months) immunosuppression may result, which necessitates prophylaxis with cotrimox-azole and antivirals to prevent opportunistic infections. [Pg.1294]

Precursor B-cell neoplasm Precursor B-lymphoblastic leukemia/lymphoma Mature (peripheral) B-cell neoplasms B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma... [Pg.1374]

Describe the clinical course of chronic lymphocytic leukemia (CLL). [Pg.1415]

Describe patients who may be observed without treatment and those who receive aggressive treatment for chronic lymphocytic leukemia (CLL). [Pg.1415]

Chronic lymphocytic leukemia (CLL) patients who receive fludarabine-based combination chemotherapy and rituximab may have long-term disease-free survival. [Pg.1415]

Cancers Multiple myeloma Non-Hodgkin s lymphoma Hodgkin s disease Acute myeloid leukemia Neuroblastoma Germ cell tumors Acute myeloid leukemia Acute lymphoblastic leukemia Chronic myeloid leukemia Myelodysplastic syndrome Myeloproliferative disorders Non-Hodgkin s lymphoma Hodgkin s disease Chronic lymphocytic leukemia Multiple myeloma... [Pg.1448]

Chronic lymphocytic leukemia (especially bulky lymphadenopathy)... [Pg.1486]

CLL Chronic lymphocytic leukemia DTR Deep-tendon reflex... [Pg.1554]

ZAP-70 expression An intracellular tyrosine kinase found in B cells in chronic lymphocytic leukemia. [Pg.1579]

Jones D, Benjamin RJ, Shahsafaei A, Dorfman DM. The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia. Blood 2000 95 627-632. [Pg.346]

Till KJ, Lin K, Zuzel M, Cawley JC. The chemokine receptor CCR7 and a4 inte-grin are important for migration of chronic lymphocytic leukemia cells into lymph nodes. Neoplasia 2002 99 2977-2984. [Pg.347]

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