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Monoamine inhibitors

Zl. Zeller, E. A., Some remarks about monamine oxidase and monoamine inhibitors. J. Neuropsychiat. Suppl. 1, 125-130 (1960). [Pg.250]

Buspirone interacts with monoamine inhibitors and can cause the serotonin syndrome (55). [Pg.83]

Figure 10.22. Hypothetical mechanism of the antihypertensive effect of monoamine inhibitors. This mechanism does not fit the observation of the cheese reaction , in which tyramine contained in fermented food causes hypertensive episodes in patients receiving monoamine oxidase blockers. Figure 10.22. Hypothetical mechanism of the antihypertensive effect of monoamine inhibitors. This mechanism does not fit the observation of the cheese reaction , in which tyramine contained in fermented food causes hypertensive episodes in patients receiving monoamine oxidase blockers.
Patients receiving monoamine oxidase inhibitors (MAOI) as antidepressant therapy have been especially subject to the hypertensive effects of vasoactive amines (52). These dietary amines have also been impHcated as causative agents ia migraine. Other aaturaHy occurring alkaloids (qv) have been recognized for centuries as possessing neurological stimulant and depressant properties. [Pg.478]

Treatment of Major Depression. Dmgs commonly used for the treatment of depressive disorders can be classified heuristicaHy iato two main categories first-generation antidepressants with the tricycHc antidepressants (TCAs) and the irreversible, nonselective monoamine—oxidase (MAO) inhibitors, and second-generation antidepressants with the atypical antidepressants, the reversible inhibitors of monoamine—oxidase A (RIMAs), and the selective serotonin reuptake inhibitors (SSRIs). Table 4 fists the available antidepressants. [Pg.229]

Monoamine—Oxidase Inhibitors. In the mid-1950s, tuberculosis patients with depression being treated with iproniazid (42) were occasionally reported to become euphoric. This observation led to the discovery of irreversible monoamine—oxidase (MAO) inhibiting properties. Hydrazine and nonhydrazine-related MAO inhibitors were subsequentiy shown to be antidepressants (122). Three other clinically effective irreversible MAO inhibitors have been approved for treatment of major depression phenelzine (43), isocarboxazid (44), and tranylcypromine (45). [Pg.230]

Reversible Inhibitors of Monoamine Oxidase. Selective MAO-A inhibitors, which aie leveisible (so-called RIMAs), have also been developed, theiefoie substantially leduciag the potential foi food and dmg iateiactions. Indeed, the tyiamine-potentiating effects of these dmgs is much reduced compared with the irreversible MAO inhibitors. The RIMAs represent effective and safer alternatives to the older MAO inhibitors. The only marketed RIMAs ate toloxatone [29218-27-7] and moclobemide (55). The latter is used widely as an effective, weU-tolerated antidepressant. [Pg.233]

Monoamine Oxidase Inhibitors. MAOIs inactivate the enzyme MAO, which is responsible for the oxidative deamination of a variety of endogenous and exogenous substances. Among the endogenous substances are the neurotransmitters, norepinephrine, dopamine, and serotonin. The prototype MAOI is iproniazid [54-92-2] (25), originally tested as an antitubercular dmg and a close chemical relative of the effective antitubercular, isoniazid [54-85-3] (26). Tubercular patients exhibited mood elevation, although no reHef of their tuberculosis, following chronic administration of iproniazid. In... [Pg.465]

Normally, dietary tyramine is broken down in the gastrointestinal tract by MAO and is not absorbed. In the presence of MAOI, however, all of its potent sympathomimetic actions are seen. Other side effects of MAOI include excessive CNS stimulation, orthostatic hypotension, weight gain, and in rare cases hepatotoxicity. Because the monoamine oxidase inhibitors exhibit greater toxicity, yet no greater therapeutic response than other, newer agents, clinical use has been markedly curtailed. The primary use for MAOIs is in the treatment of atypical depressions, eg, those associated with increased appetite, phobic anxiety, hypersomnolence, and fatigues, but not melancholia (2). [Pg.466]

Pharmacologically useful isoxazoles (B-82MI41600) include antibacterial sulfonamides (614), (615) and (616), semisynthetic penicillins (617), (618), (619) and (620), semisynthetic cephalosporin (621), anabolic steroid (622), the monoamine oxidase inhibitor (623) (used in psychotherapy), antiinflammatory agent (624) and antitumor agent (625). [Pg.127]

Pargyline hydrochloride (Eutonyl, (V-methyl-n-propargylbenzylamine hydrochloride) [306-07-0] M 195.7, m 154-155 , 155 , pK 6.9. Recrystd from EtOH-Et20 and dried in vacuo. It is very soluble in H2O, in which it is unstable. The free base has b 101-103°/ 1mm. It is a glucuronyl transferase inducer and a monoamine oxidase inhibitor, [von Braun et al. Justus Liebigs Ann Chem 445 205 1928, Yeh and Mitchell Experientia 28 298 1972 Langslrom et al. Science 225 1480 1984.]... [Pg.556]

Monoamine oxidase (MAO) inactivates serotonergic and catecholaimnergic neurotransmitters MAO (A and B) inhibitors exhibit mood elevatmg properties 5-Fluoro-Ot-methyltryptamine 19) is an important MAO A-seleUive inhibitor In the treatment of certam depressive illnesses, 4-fluorotranylcypromine (20b) is 10 tunes more potent than the parent tranylcypromme (TCP, 20a) The enhanced m vivo activity may be due to increased lipophihcity at20b and/or to blockade of metabohc para hydroxylation [52]... [Pg.1017]

MAO (monoamine oxidase) inhibitor. An agent that blocks one of the enzymes that deaminates amines. [Pg.453]

Therapeutic Function Antidepressant monoamine oxidase inhibitor Chemical Name 4-Pyridinecarboxylic acid 2-(1-methylethyl)hydrazide Common Name —... [Pg.837]

Antidepressants are used in the treatment of neuropathic pain and headache. They include the classic tricyclic compounds and are divided into nonselective nor-adrenaline/5-HT reuptake inhibitors (e.g., amitriptyline, imipramine, clomipramine, venlafaxine), preferential noradrenaline reuptake inhibitors (e.g., desipramine, nortriptyline) and selective 5-HT reuptake inhibitors (e.g., citalopram, paroxetine, fluoxetine). The reuptake block leads to a stimulation of endogenous monoaminer-gic pain inhibition in the spinal cord and brain. In addition, tricyclics have NMDA receptor antagonist, endogenous opioid enhancing, Na+ channel blocking, and K+ channel opening effects which can suppress peripheral and central sensitization. Block of cardiac ion channels by tricyclics can lead to life-threatening arrhythmias. The selective 5-HT transporter inhibitors have a different side effect profile and are safer in cases of overdose [3]. [Pg.77]

Neurotransmitter Transporters Monoamine Oxidases and their Inhibitors... [Pg.441]

Monoamine oxidases Inhibitors Depressive illness Parkinson s disease Neuroprotection neurorescue... [Pg.783]

Ubiquitous mitochondrial monoamine oxidase [monoamine oxygen oxidoreductase (deaminating) (flavin-containing) EC 1.4.3.4 MAO] exists in two forms, namely type A and type B [ monoamine oxidase (MAO) A and B]. They are responsible for oxidative deamination of primary, secondary, and tertiary amines, including neurotransmitters, adrenaline, noradrenaline, dopamine (DA), and serotonin and vasoactive amines, such as tyramine and phenylethylamine. Their nonselec-tive and selective inhibitors ( selective MAO-A and -B inhibitors) are employed for the treatment of depressive illness and Parkinson s disease (PD). [Pg.783]

Monoamine Oxidases and their Inhibitors. Table 1 Substrate specificity of the two forms of rat liver and brain monoamine oxidase... [Pg.783]


See other pages where Monoamine inhibitors is mentioned: [Pg.338]    [Pg.338]    [Pg.645]    [Pg.218]    [Pg.228]    [Pg.465]    [Pg.465]    [Pg.469]    [Pg.255]    [Pg.675]    [Pg.676]    [Pg.704]    [Pg.709]    [Pg.574]    [Pg.574]    [Pg.43]    [Pg.78]    [Pg.112]    [Pg.351]    [Pg.438]    [Pg.442]    [Pg.493]    [Pg.507]    [Pg.605]    [Pg.783]    [Pg.783]    [Pg.783]    [Pg.784]   
See also in sourсe #XX -- [ Pg.478 , Pg.482 , Pg.484 , Pg.485 , Pg.493 , Pg.528 , Pg.530 , Pg.537 ]




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Aggression monoamine oxidase inhibitor

Amfetamine Monoamine oxidase inhibitors

Amitriptyline Monoamine oxidase inhibitors

Amphetamines monoamine oxidase inhibitors

Anticonvulsants monoamine oxidase inhibitors

Antidepressant agents monoamine oxidase inhibitors

Antidepressant drugs monoamine oxidase inhibitors

Antidepressants Monoamine oxidase inhibitors Serotonin-selective

Antidepressants monoamine oxidase inhibitors

Antihypertensives Monoamine oxidase inhibitors

Atomoxetine Monoamine oxidase inhibitors

Barbiturates Monoamine oxidase inhibitors

Bupropion Monoamine oxidase inhibitors

Buspirone monoamine oxidase inhibitors

Caffeine Monoamine oxidase inhibitors

Cheese, monoamine oxidase inhibitors

Chlorpromazine monoamine oxidase inhibitors

Citalopram Monoamine oxidase inhibitors

Cocaine monoamine oxidase inhibitors

Depression monoamine oxidase inhibitors

Depressive disorders monoamine oxidase inhibitors

Disulfiram Monoamine oxidase inhibitors

Dopamine Monoamine oxidase inhibitors

Fenfluramine monoamine oxidase inhibitors

Fluoxetine monoamine oxidase inhibitors

Fluvoxamine Monoamine oxidase inhibitors

Hormonal) Monoamine oxidase inhibitors

Hypericum extracts inhibitor of monoamine

Hypericum monoamine oxidase inhibitors

Imipramine Monoamine oxidase inhibitors

Inhibitors of monoamine oxidases

Inhibitors, monoamine reuptake

Instructions for patients taking nonselective monoamine oxidase inhibitors

Isoniazid monoamine oxidase inhibitors

Linezolid Monoamine oxidase inhibitors

Lithium monoamine oxidase inhibitors

Liver , monoamine oxidase inhibitor interaction

Look up the names of both individual drugs and their drug groups to access full information Monoamine oxidase inhibitors

Medicines) Monoamine oxidase inhibitors

Methadone Monoamine oxidase inhibitors

Methyldopa Monoamine oxidase inhibitors

Methylphenidate Monoamine oxidase inhibitors

Mirtazapine Monoamine oxidase inhibitors

Monoamine Oxidases and their Inhibitors

Monoamine oxidase A inhibitor

Monoamine oxidase MAO) inhibitors

Monoamine oxidase inhibitor MAOI)

Monoamine oxidase inhibitor contraindications

Monoamine oxidase inhibitor interaction and

Monoamine oxidase inhibitors

Monoamine oxidase inhibitors MAOIs) interactions

Monoamine oxidase inhibitors MAOls)

Monoamine oxidase inhibitors Parkinson disease

Monoamine oxidase inhibitors Parkinsonism

Monoamine oxidase inhibitors SSRIs

Monoamine oxidase inhibitors action

Monoamine oxidase inhibitors administration

Monoamine oxidase inhibitors adverse effects

Monoamine oxidase inhibitors alcohol

Monoamine oxidase inhibitors anxiety disorders

Monoamine oxidase inhibitors anxiolytics

Monoamine oxidase inhibitors applications

Monoamine oxidase inhibitors available drugs

Monoamine oxidase inhibitors cardiovascular

Monoamine oxidase inhibitors cheese effect

Monoamine oxidase inhibitors chemical structures

Monoamine oxidase inhibitors classification

Monoamine oxidase inhibitors consequences

Monoamine oxidase inhibitors development

Monoamine oxidase inhibitors dextromethorphan

Monoamine oxidase inhibitors dietary interactions with

Monoamine oxidase inhibitors discontinuation

Monoamine oxidase inhibitors discovery

Monoamine oxidase inhibitors distribution

Monoamine oxidase inhibitors dosage

Monoamine oxidase inhibitors dosing

Monoamine oxidase inhibitors drug administration

Monoamine oxidase inhibitors drug interactions

Monoamine oxidase inhibitors drug interactions with

Monoamine oxidase inhibitors drug overdose

Monoamine oxidase inhibitors drug withdrawal

Monoamine oxidase inhibitors during pregnancy

Monoamine oxidase inhibitors efficacy

Monoamine oxidase inhibitors ephedrine

Monoamine oxidase inhibitors examples

Monoamine oxidase inhibitors fluoxetine with

Monoamine oxidase inhibitors food interactions

Monoamine oxidase inhibitors food-drug interactions

Monoamine oxidase inhibitors foods

Monoamine oxidase inhibitors gastrointestinal effects

Monoamine oxidase inhibitors ginseng

Monoamine oxidase inhibitors glaucoma with

Monoamine oxidase inhibitors history

Monoamine oxidase inhibitors in Parkinson’s disease

Monoamine oxidase inhibitors in depression

Monoamine oxidase inhibitors in posttraumatic stress disorder

Monoamine oxidase inhibitors in social anxiety disorder

Monoamine oxidase inhibitors indications

Monoamine oxidase inhibitors interaction with foods

Monoamine oxidase inhibitors interaction with other drugs

Monoamine oxidase inhibitors interactions

Monoamine oxidase inhibitors lactation

Monoamine oxidase inhibitors levodopa

Monoamine oxidase inhibitors limitations

Monoamine oxidase inhibitors liver

Monoamine oxidase inhibitors long-term effects

Monoamine oxidase inhibitors mechanism

Monoamine oxidase inhibitors mechanism of action

Monoamine oxidase inhibitors monitoring

Monoamine oxidase inhibitors nefazodone

Monoamine oxidase inhibitors nervous system

Monoamine oxidase inhibitors neuroleptic drugs

Monoamine oxidase inhibitors nonselective

Monoamine oxidase inhibitors opioid analgesics

Monoamine oxidase inhibitors overdose

Monoamine oxidase inhibitors patient information

Monoamine oxidase inhibitors pharmacological properties

Monoamine oxidase inhibitors phenylephrine

Monoamine oxidase inhibitors pregnancy

Monoamine oxidase inhibitors restrictions

Monoamine oxidase inhibitors selective

Monoamine oxidase inhibitors selective irreversible

Monoamine oxidase inhibitors side effects

Monoamine oxidase inhibitors social anxiety

Monoamine oxidase inhibitors structure

Monoamine oxidase inhibitors structure-activity relationship

Monoamine oxidase inhibitors sumatriptan

Monoamine oxidase inhibitors therapeutic efficacy

Monoamine oxidase inhibitors trazodone

Monoamine oxidase inhibitors tricyclic antidepressants

Monoamine oxidase inhibitors tricyclic antidepressants with

Monoamine oxidase inhibitors uses

Monoamine oxidase inhibitors values

Monoamine oxidase inhibitors venlafaxine

Monoamine oxidase inhibitors with methylphenidate

Monoamine oxidase inhibitors, role

Monoamine oxidase irreversible inhibitors

Monoamine oxidase type B inhibitors

Monoamine transporters serotonin reuptake inhibitor

Monoamine uptake inhibitors

Monoamine-oxidase B inhibitors

Monoamine-synthesis inhibitor

Monoamine-synthesis inhibitor inhibition of antinociception

Morphine Monoamine oxidase inhibitors

Non-selective Monoamine Reuptake Inhibitor

Older Antidepressants Tricyclics and Monoamine Oxidase Inhibitors

Opioids monoamine oxidase inhibitors

Panic disorder monoamine oxidase inhibitors

Paroxetine Monoamine oxidase inhibitors

Pharmacokinetics monoamine oxidase inhibitors

Phenothiazines Monoamine oxidase inhibitors

Postural hypotension, with monoamine oxidase inhibitors

Procarbazine monoamine oxidase inhibitors

Prozac Interaction With Monoamine Oxidase Inhibitors and Tryptophan

Pseudoephedrine Monoamine oxidase inhibitors

Psychotropic agents monoamine oxidase inhibitors

RIMAs (Reversible inhibitors of monoamine oxidase

Rasagiline Monoamine oxidase inhibitors

Reserpine Monoamine oxidase inhibitors

Reversible inhibitor of monoamine

Reversible inhibitor of monoamine oxidase A

Reversible inhibitor of monoamine oxidase type A

Reversible inhibitors of monoamine oxidase

Reversible inhibitors of monoamine oxidase type

Reversible monoamine oxidase inhibitors

Reversible monoamine oxidase inhibitors RIMA) type

Selective serotonin reuptake inhibitors monoamine oxidase

Selegiline Monoamine oxidase inhibitors

Sertraline Monoamine oxidase inhibitors

Social anxiety disorder monoamine oxidase inhibitors

Tramadol Monoamine oxidase inhibitors

Tricyclic antidepressants and monoamine oxidase inhibitors

Triptans Monoamine oxidase inhibitors

Tyramine, dietary, monoamine oxidase inhibitor

Tyramine, monoamine oxidase inhibitors

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