Monoamine oxidase inhibitors lactation

The skeletal muscle relaxants are contraindicated in patients with known hypersensitivity. Baclofen is contraindicated in skeletal muscle spasms caused by rheumatic disorders. Carisoprodol is contraindicated in patients with a known hypersensitivity to meprobamate. Cyclobenzaprine is contraindicated in patients with a recent myocardial infarction, cardiac conduction disorders, and hyperthyroidism, hi addition, cyclobenzaprine is contraindicated within 14 days of the administration of a monoamine oxidase inhibitor. Oral dantrolene is contraindicated in patients with active hepatic disease and muscle spasm caused by rheumatic disorders and during lactation. See Chapter 30 for information on diazepam. 

Scheme 16. Flavin photochemistry with propargylamine substrate. Competing substrate carbon atoms 1 and 3 lead to new adduct chromophores, which are identical with the chromophores of enzyme (Monoamine Oxidase = MAO and Lactate Oxidase = LO) inhibitor adducts...

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