Monoamine oxidase inhibitors antidepressants

Therapeutic Function Antidepressant monoamine oxidase inhibitor Chemical Name 4-Pyridinecarboxylic acid 2-(1-methylethyl)hydrazide Common Name —... 

The hypotensive effects of most antihypertensive dru are increased when administered with diuretics and other antihypertensives. Many dnigp can interact with the antihypertensive drugs and decrease their effectiveness (eg, antidepressants, monoamine oxidase inhibitors, antihistamines, and sympathomimetic bronchodilators). When the ACE inhibitors are administered with the NSAIDs, their antihypertensive effect may be decreased. Absorption of the ACE inhibitors may be decreased when administered with the antacids. Administration of potassium-sparing diuretics or potassium supplements concurrently with the ACE inhibitors may cause hyperkalemia. When the angiotensin II receptor agonists are administered with... 

Tricyclic antidepressants Monoamine oxidase inhibitors Selective serotonin reuptake inhibitors Antipsychotics Phenothiazines Risperidone Lithium... 

Bonson KR, Buckholtz JW, Murphy DL. (1996). Chronic administration of serotonergic antidepressants attenuates the subjective effects of LSD in humans. Neuropsychopharmacology. 14(6) 425-36, Bonson KR, Murphy DL. (1996). Alterations in responses to LSD in humans associated with chronic administration of tricyclic antidepressants, monoamine oxidase inhibitors, or lithium. Behav Brain Res. 73(1-2) 229-33. 

Drug withdrawal reactions - tricyclic antidepressants, monoamine oxidase inhibitors, benzodiazepines, barbiturates, alcohol, opioids. 

Dmg-induced serotonin syndrome is generally mild and resolves when the offending drugs are stopped. However, it can be severe and deaths have occurred. A large number of drugs have been implicated including tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), selective serotonin re-uptake inhibitors (SSRIs), pethidine, lithium, and dextromethorphan. The most severe type of reaction has occurred with the combination of selective serotonin re-uptake inhibitors and monoamine oxidase inhibitors. Both non-selective MAOIs such as phenelzine and selective MAOIs such as moclobemide and selegiline have been implicated. 

SRls are currently the most prevalent pharmacological treatment used for panic disorder [see Westenberg and Den Boer, Chapter 24, in this volume], even though tricyclic antidepressants, monoamine oxidase inhibitors [MAOls], and benzodiazepines are also effective. The efficacy of the SRI antidepressants and the observation that initially they may induce deterioration of symptoms [which is usually not the case with treatment of depressed patients with the same medications] raise issues related to the pathobiology of anxiety and its comorbidity with depression. 

Seiective Serotonin Reuptake,I,n,h,i,y,tor,Plasma,Levels,and Other Antidepressants Monoamine Oxidase Inhibitors Conclusion... 

Dianthrone derivatives Hypericin, pseudohypericin, anthranol, photohypericin, hypericodehydrodianthrone Flavanols Catechin polymers (condensed tannins), leucocyanidin, epicatechin Photodynamic, antidepressant [monoamine oxidase inhibitor (MAOI)], antiviral Astringent, anti-inflammatory, styptic, antiviral... 

Arguably the first modern class of antidepressants, monoamine oxidase inhibitors (MAOIs) were introduced in the 1950s but are now rarely used in clinical practice because of toxicity and potentially lethal food and drug interactions. Their primary use now is in the treatment of depression unresponsive to other antidepressants. However, MAOIs have also been used historically to treat anxiety states, including social anxiety and panic disorder. In addition, selegiline is used for the treatment of Parkinson s disease (see Chapter 28). 

Classical Antidepressants Monoamine Oxidase Inhibitors and Tricyclic Antidepressants... 

The precise mechanism by which the first-generation tricyclic antidepressants, monoamine oxidase inhibitors, and the newer-generation antidepressants exert their effects is uncertain. However, it is clear that antidepressants exert their effects at both pre- and postsynaptic receptor sites (Figure 43.3 and Figure 43.4). 

Bonson KR, Murphy DL. Alterations in responses to LSD in humans associated with chronic administration of tricyclic antidepressants, monoamine oxidase inhibitors or lithium. Behav Brain Res 1996 73(l-2) 229-33. 

Some antidepressants—specifically, tricyclics like imipramine (trade name Tofranil) and amitryptiline (trade name Elavil)—are thought to exert their antidepressant effect through inhibition of a reuptake mechanism that sucks back the neurotransmitters from the synapse into the neuron for storage and future use, a process mentioned in Chapter 1. The resulting net effect is an increase of these molecules at the synapse and thus a more robust neurotransmission. A different category of antidepressants—monoamine oxidase inhibitors (MAOIs)—display a different mechanism of action but with the same net effect of increasing norepinephrine and serotonin neurotransmission they inhibit the metabolism (breakdown) of the molecules stored in the neurons, thus creating more abundant supplies for neurotransmission. 

NERVOUS SYSTEM DRUGS ANTIDEPRESSANTS Monoamine oxidase inhibitors... 

LINEZOLID - Drugs Acting on the Nervous System, Antidepressants, Monoamine oxidase inhibitors ... 

Clorgyline Antidepressant (Monoamine Oxidase Inhibitor) Synonym. Clorgiline... 

Isocarboxazid Antidepressant (Monoamine Oxidase Inhibitor) Proprietary Name. Marplan 2 -Benzyl-5-methylisoxazole-3-carbohydrazide Ci2Hi3N302 = 231.3... 

Tricyclic antidepressants, monoamine oxidase inhibitors Over-the-counter antihistamines, decongestants Allergies (preservatives, penicillins, sulfonamides, neomycin, opioids)... 

Antidepressants monoamine oxidase inhibitors can cause hypertension when combined with certain amines, e.g. pethidine, or indirect-acting sympa-thomimetics, e.g. ephedrine. Tricyclics potentiate catecholamines and some other adrenergic drugs. 

Gonadotropin-releasing hormone analogs Benzodiazepines Tricyclic antidepressants Monoamine oxidase inhibitors Hz-Receptor antagonists Opioids Other Verapamil... 

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