Linezolid Monoamine oxidase inhibitors

Drugs that may interact with linezolid include monoamine oxidase inhibitors, SSRIs, and adrenergic agents (eg, dopamine, epinephrine). 

SSRIs can provoke 5HT neurotoxicity (the 5HT syndrome) through pharmacodynamic interactions with other drugs that also potentiate 5HT function. Often the ability of the interacting drug to facilitate 5HT function is well known, as is the case, for example, when SSRIs are combined with monoamine oxidase inhibitors or lithium. In other cases, however, the potential 5HT activity of the co-administered drug is not widely known. The ability of the antibiotic linezolid to inhibit MAO and thereby to cause 5HT neurotoxicity in combination with SSRIs has been noted previously (SEDA-27, 14), and further cases have now been reported. 

LINEZOLID - Drugs Acting on the Nervous System, Antidepressants, Monoamine oxidase inhibitors ... 

Hartaian CS, Leach TS, Todd WM, Hafkin B. Lack of drug-interaction with combination of linezolid and monoamine oxidase inhibitor-interacting medications. Pharmacotherapy... 

Serotonin reuptake inhibitors Linezolid is a reversible inhibitor of monoamine oxidase and can cause drug-drug interactions when it is combined with monoamine oxidase inhibitors, monoamines such as adrenaline and noradrenaline, tyramine-containing foods, and other serotonergic agents. Several cases of serotonin syndrome have been reported... 

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