Caffeine Monoamine oxidase inhibitors

There are theoretical drug interactions with caffeine and monoamine oxidase inhibitors. Caffeine could increase risk of cardiovascular events when taken with C. aurantium (54). The case report of MI (45) and several of the Canadian reported adverse events included caffeine (46). Synephrine, tyramine, and octopamine are all substrates of monoamine oxidase (55). Taking a monoamine oxidase inhibitor with C. aurantium could increase concentrations of these sympathomimetics, and thus should be avoided. 

Health Canada s Natural Health Products Directorate (NHPD) has concluded that daily use by healthy adults of p-synephrine at up to 50 mg, or up to 40 mg in combination with up to 320 mg of caffeine, would generally result in a Type III risk classification. This classification is defined to mean that such use "is not likely to cause any adverse health consequences." On the other hand, NHPD determined that products that contain p-synephrine but lack certain cautionary statements, identified as "contraindicated in children, pregnancy, and breast-feeding, do not use if you are taking blood pressure medications (either hypertensives or antihypertensives), thyroid medications, sympathomimetics, or monoamine oxidase inhibitors," would be subject to a Type II risk classification (meaning "the use of, or exposure to, such a product may cause temporary adverse hedth consequences or where the probability of serious adverse health consequences is remote") (Maries 2011). 

ASA = aspirin NSAIDs = non-steroidal anti-inflammatory drugs, such as ibuprofen, naproxen, and diclofenac CNS stimulants include drugs such as pseudoephedrine, dextroamphetamine, theophylline, and caffeine MAO = monoamine oxidase CNS depressants include drugs such as benzodiazepines, barbiturates, and ethanol SSRIs = selective serotonin reuptake inhibitors, such as fluoxetine, sertraline, and paroxetine. Antidiabetic agents include drugs such as insulin, glipizide, glyburide, and metformin. 

Acetylcholinesterase inhibitors Alzheimer s disease caffeine cholinergic dopaminergic monoamine oxidase muscarinic receptor nicotinic receptor Parkinson s disease Vinca... 

---