Procarbazine monoamine oxidase inhibitors

Myelosuppression is the major side effect. Nausea, vomiting, and a flulike syndrome occur initially with therapy. Patients must be counseled to avoid tyramine-rich foods because procarbazine is a monoamine oxidase inhibitor. Patients should be provided a list of foods and beverages to avoid to prevent a hypertensive crisis. A disulhramlike reaction can occur with the ingestion of alcohol. 

Procarbazine can cause a disulfiram-like reaction and is a monoamine oxidase inhibitor. Thus, ingestion of alcohol, foods containing tyramine (e.g., cheese), drugs that increase sympathetic activity, and MAOl-type antidepressants (e.g., tranylcypromine) should be avoided. 

Procarbazine hydrochloride An+, D+, En+, G++, M++, N++ Monoamine oxidase inhibitor activity. Disulfiram-like ethanol interaction. 

The mechanism of action of procarbazine is uncertain however, the drug inhibits the synthesis of DNA, RNA, and protein prolongs interphase and produces chromosome breaks. Oxidative metabolism of this drug by microsomal enzymes generates azoprocarbazine and H202, which may be responsible for DNA strand scission. A variety of other metabolites of the drug are formed that may be cytotoxic. One metabolite is a weak monoamine oxidase (MAO) inhibitor, and adverse side effects can occur when procarbazine is given with other MAO inhibitors. 

Procarbazine is a weak inhibitor of monoamine oxidase adverse drug and food interactions can occur, for example with tyramine-containing foods and drinks,... 

Examples of interactions occurring at receptor sites include problems involving the use of the monoamine oxidase (MAO) inhibitors [isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane)]. 

The manufacturers say that procarbazine is a weak inhibitor of MAO and therefore predict that interactions with certain foods and drugs may occur in rare cases. This is apparently based on the results of animal experiments, which show that the monoamine oxidase inhibitory properties of procarbazine are weaker than pheniprazine. There seem to be no formal reports of hypertensive reactions in patients taking procarbazine who have... 

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