Medicines Monoamine oxidase inhibitors

The term pasaon flower is used to denote many of the approximately 400 species of the herb. F saon flower has been used in medicine to treat pain, anxiety, and insomnia. Some herbalists use the herb to treat symptoms of parkinsonism. F saon flower is often used in combination with other herbs , such a valerian, chamomile, and hops, for promoting relaxation, rest and sleep. Although no adverse reactions have been reported, large doses may cause CNS depression. The use of passion flower is contraindicated in pregnancy and in patientstaking the monoamine oxidase inhibitors (MAOIs). Fission flower contains coumarin, and the risk of bleeding may be increased when used in patientstaking warfarin and pasaon flower. 

Q8 A pregnancy test is necessary because hypertension is a feature of preeclampsia, a serious condition which can occur in pregnancy and which threatens the life of both mother and foetus. Also, many antihypertensive drugs are contraindicated in pregnancy. It is necessary to know whether the patient is taking prescribed medicines or is self-medicating, as some drugs, such as monoamine oxidase inhibitors (MAOIs), can interact with dietary components to cause a very rapid rise in BP. 

Interactions of antidepressants with herbal medicines have been reported (53). Ginseng has been reported to cause mania, tremor, and headache when used in combination with conventional monoamine oxidase inhibitors. 

Carbamazepine is contraindicated in patients taking monoamine oxidase inhibitors (101,102). The combination can cause sudden high body temperature, extremely high blood pressure, and severe convulsions at least 14 days should be allowed between stopping treatment with one medicine and starting the other. 

Linden CH, Rumack BH, and Strehlke C (1984) Monoamine oxidase inhibitor overdose. Annals of Emergency Medicine 13 1137-1144. 

The ephedra alkaloids are all sympathomimetic amines, which means that a host of drug interactions are theoretically possible. In fact, only a handful of adverse drug interactions have been reported in the peer-reviewed literature. The most important of these involve the monoamine oxidase inhibitors (MAOI). Irreversible, nonselective MAOIs have been reported to adversely interact with indirectly acting sympathomimetic amines present in many cough and cold medicine. In controlled trials with individuals taking moclobemide, ephedrine s effects on pulse and blood pressure were potentiated, but only at higher doses than those currently provided in health supplements (137). Ephe-drine-MAOI interaction may, on occasion, be severe enough to mimic pheo-... 

MAOI and SSRI are acronyms for two types of antidepression medication. MAOI stands for monoamine oxidase inhibitor. MAOIs must be prescribed and used with caution because they tend to dangerously interact with other types of drugs.Today, other forms of antidepressants are usually prescribed for depression patients first. If those medicines do not work, MAOIs are sometimes used with caution. People taking MAOIs have to restrict their diets and watch what other drugs and medicines they take in order to prevent interactions. SSRI, an antidepressant that is more commonly used, stands for selective serotonin reuptake inhibitor.They are generally able to be tolerated by more people and can be used for more minor depressive illnesses. 

Direct-to-consumer advertisements of pharmaceutical products are allowed in the United States. It is not uncommon to hear a TV commercial about a medicinal product stating that the product is not to be used by certain patients. For example, advertisements for Cymbalta will typically include a statement that "patients using a MAOl (monoamine oxidase inhibitor) medication or patients with uncontrolled narrow-angle glaucoma should not take Cymbalta." Statements such as this reinforce the message that the risk of a product may outweigh its potential benefit for some patients. 

It is known that pyrazolines and pyrazoles are an important class of pharmacophores [1,2,3,4, 5,6], Heterocycles containing these fragments are important targets in synthetic and medicinal chemistry since they are key moieties in numerous biologically active compounds possessing tranquilizing, muscle relaxant, psychoanaleptic, anticonvulsant and antidepressant activities [7, 8, 9,10,11,12], This includes kinesin spindle protein [12] and monoamine oxidase [13, 14] inhibitors as well as antimycobacterial [15, 16] and anti-inflammatory [17] agents. 

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