Mean cell volume

Mean cell volume (MCV) 80-96 fL/cell A widely used laboratory value to measure RBC "size" higher values indicate macrocytosis and lower values indicate microcytosis. 

The hypothesis is supported by two additional observations (24). First, mean cell volume for P. brevis in the absence of aponin remained constant for 8 hours, but, in the presence of aponin, a notable increase was observed within an hour and continued for eight hours. Second, Trypan blue (Cl 23850) tests indicated increased cell permeability in the presence of aponin viable, motile cells were only slightly stained swollen cells and cell debris were highly stained. 

This study is supported by intermediate-duration NOAELs for hematological effects of 75 mg/kg/day in a dog study (Hart 1980) and 45 mg/kg/day (males) and 57 mg/kg/day (females) in a mink study (Bucci et al. 1997). In the Bucci et al. (1997) mink study, the next highest level, 262 or 330 mg/kg/day in males and females, respectively, produced hematological changes that included increased Heinz body counts, reticulocytes, mean cell volume, and decreased RBC counts. 

Mean cell volume Anemias Iron deficiency... 

Mean cell volume (MCV) White cell count and platelet 91 fl (ref 80-98 fl)... 

Alcohol consumption is very difficult to assess. There is widespread belief that individuals underreport their intake and there are no reliable laboratory tests available for definitive diagnosis of alcohol abuse. A combination of abnormalities in the plasma activity of gamma-glutamyl transferase (GGT or yGT), AST and reduction in erythrocyte mean cell volume (MCV) maybe useful and all are routine lab. tests. A potential marker of interest is carbohydrate-deficient transferrin (CDT) which is an abnormal isoform of serum transferrin arising due to defects in the attachment of carbohydrate chains to the protein core. Unfortunately, CDT is a somewhat specialized test, not performed by most laboratories. Other markers which have attracted some research interest are ethyl sulphate and ethyl glucuronide. Excretion in the urine of these metabolites occurs for up to 50 hours after binge drinking so they offer a useful index of recent heavy alcohol intake. 

A woman 7 months pregnant with her first child develops anemia. Laboratory evaluation indicates an increased mean cell volume (MVC), hypeisegmented neutrophils, and altered morphology of several other cell types. The most likely underlying cause of this woman s... 

MCV, mean cell volume MCHC, mean cell hemoglobin concentration SI, serum iron TIBC, transferrin iron-binding capacity. 

It has been further reported that not only the calcium metabolism but also other minerals and other aspects of mineral status may be influenced by CPPs. Ait-Oukhatar et al. (1997) found that in young iron-deficient rats, CPP-bound iron had a positive effect on some parameters of iron status and metabolism, such as mean cell volume, haemoglobulin and haematocrit, and a negative effect on some parameters, such as urine iron. Other parameters,... 

Transcorrin II bound vitamin B12 Mean cell volume Serum methylmalonic acid Serum homocysteine Urine FIGLU more than 8 h after histidine load — <0.15 <0.22 >100 fL >1 i.mol/L >20 i.mol/L >50 [ig /mL ... 

Individual mean cell volumes assumed from literature values and converted to wet weight (1 J.m = 1 pg wet weight) and dry weight (dry weight = 0.2 X wet weight) (Caron and... 

Patients with this abnormality suffer from mild hypochromic anemia with microcytosis and signs of hemolysis a highly characteristic property is the 2- to 3-fold increase in the relative production of Hb-Aa. The Hb-level may vary between 7.5 and 11.5 g/100 ml. Anemia is the most common disturbance followed by hepatomegaly, gall stones, jaundice, splenomegaly, and others (G5). The red blood cell count varies between 5.5 and 7,5 million/mm with mean cell volumes (MCV) of 55-80 and mean cellular hemoglobin concentrations (MCHC) of 25-30%. The peripheral blood film shows hypochromia and microcytosis,... 

A 30-year-old woman had a hemoglobin concentration of 3.1 g/dl, a mean cell volume of 77 fl, a reticulocyte count of 2.13%, a platelet count of 426 x 10 /1, a serum iron concentration of 5 ng/ml, a transferrin saturation of 1%, and a ferritin concentration of 8 ng/ml. She was intolerant of oral iron and was given intramuscular iron dextran, 100 mg/day for 8 days, when she developed asymptomatic thrombocytopenia (platelet count 20 X 10 /1). Iron dextran was withdrawn and she took oral ferrous fumarate 200 mg/day plus ascorbic acid 120 mg/day. Within 2 days her platelet count improved. 

Almost uniformly, zidovudine treatment results in a progressive increase in the erythrocjTe mean cell volume, which cannot be prevented by supplementation with vitamin B12 and folinic acid (15). Zidovudine can cause anemia (16) and reversible pure red cell aplasia (17). While recombinant erythropoietin is useful in correcting... 

Both the hematocrit values and the red cell counts (A) show much the same story. When these values were used to compute the mean corpuscular hemoglobin concentration (Figure 3) and the mean cell volumes (Figure 4) it was found that indeed a microcytic hypochromic anemia had been produced at the lowest iron intake levels.- However, the effect was much more pronounced when 20% protein was fed than when the diet contained 10% casein. 

In vitro studies have shown that, compared to rat blood cells, human red blood cells are insensitive to the hemolytic effects of 2-butoxyacetic acid. Concentrations of 2-butoxyacetic acid that caused hemolysis of rat red blood cells did not cause hemolysis of human red blood cells (Bartnik et al. 1987). For example, following a 60-minute exposure of rat red blood cells to 7.5 mM 2-butoxyacetic acid, 100% hemolysis was observed. Following a 60-minute exposure of human red blood cells to 15 mM 2-butoxyacetic acid, no hemolysis was observed (Bartnik et al. 1987). An in vitro study measuring more sensitive end points of red blood cell effects, i.e., mean cell volume and hematocrit, has also shown rat red blood cells to be more sensitive to 2-butoxyacetic acid compared to human red blood cells (Ghanayem and Sullivan 1993). For example, following a 1-hour exposure to 2 mM 2-butoxyacetic acid, mean corpuscular volume was... 

Table 6. Effect of BR on cell growth in liquid condition. 1000 cell units/ml were inoculated in each 2 ml samples. After 10 days of growth, the packed cell volume and the mean cell volume were determined. (Reproduced with permission from reference 27. Copyright 1988 Elsevier.)...

BR-6 10 bM Cell number x 105 Packed cell volume ml Mean cell volume... 

Figure 2. Distributions of cell volumes of typical red cell and ghost cell preparations, obtained by Coulter counter. Key to mean cell volumes red cells, 87 ixm3 and ghost cells, 76 ixm3.

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