Hematology changes

Serious hepatotoxicity of tacrine has been documented. More recent data suggest, however, that this toxicity can be reduced by carehiUy monitoring semm alanine aminotransferase levels (125). The side effects of tacrine also include gastrointestinal disturbances and emesis, and alternative AChE therapies are being advanced. Velnacrine (20), a metaboUte of tacrine, was expected to have reduced hepatotoxicity. However, its limited efficacy and side-effect profile, which includes dmg-related hematological changes, caused it to be dropped from further development. 

The incidence of adverse reactions appears to be higher when larger doses of isoniazid are prescribed. Adverse reactions include hypersensitivity reactions, hematologic changes, jaundice, fever, skin eruptions, nausea, vomiting, and epigastric distress. Severe, and sometimes fatal, hepatitis has been associated witii isoniazid tiierapy and may appear after many months of treatment. Peripheral neuropathy (numbness and tingling of the extremities) is the most common symptom of toxicity. 

Nausea, vomiting, epigastric distress, heartburn, fatigue, dizziness, rash, hematologic changes, and renal insufficiency may be seen witii administration of rifampin. Rifampin may also cause a reddish-orange discoloration of body fluids, including urine, tears, saliva, sweat, and sputum. 

Which of die following hematologic changes may result from the administration of dapsone ... 

Adverse reactions associated with zidovudine include headache, weakness, malaise, nausea, abdominal pain, and diarrhea. Hematologic changes include anemia and granulocytopenia (low levels of granulocytes, atype of white blood cell, in the blood). 

The use of quinine can cause cinchonism at full therapeutic doses. Cinchonism is a group of symptoms associated with quinine, including tinnitus, dizziness, headache, gastrointestinal disturbances, and visual disturbances. These symptoms usually disappear when the dosage is reduced. Other adverse reactions include hematologic changes, vertigo, and skin rash. 

Rash, exfoliative dermatitis, Sevens-Johnson syndrome, nausea, vomiting, diarrhea, abdominal pain, hematologic changes... 

Administration of trimethadione (Tridione) may result in hematologic changes, such as pancytopenia (decrease in all the cellular components of the blood), leukopenia, aplastic anemia, and thrombocytopenia Also reported are various types of skin rashes, diplopia (double vision), vomiting, changes in blood pressure, CNS depression, photosensitivity, and fatal nephrosis. Because these dm have been associated with serious adverse reactions and fetal malformations, they should be used only when other less toxic dm are not effective in controlling seizures. The oxazolidinediones may precipitate a tonic-clonic seizure... 

Gastrointestinal symptoms occur frequently with the administration of ethosuximide (Zarontin), methsux-imide (Celontin Kapseals), and phensuximide (Milontin Kapseals). Mental confusion and other personality changes, pruritus, urticaria, urinary frequency, weight loss, and hematologic changes may also be seen. 

Fever, rash, paresthesias, photosensitivity, crystalluria, acidosis, urticaria, pruritus, hematuria, weakness, malaise, anorexia, hematologic changes, convulsions... 

Electrolyte imbalances, anorexia, nausea, vomiting, dizziness, rash, photosensitivity reactions, postural or orthostatic hypotension, glycosuria Electrolyte imbalances, anorexia, nausea, vomiting, fever, chills, anxiety, confusion, hematologic changes me as bumetanide... 

This study is supported by intermediate-duration NOAELs for hematological effects of 75 mg/kg/day in a dog study (Hart 1980) and 45 mg/kg/day (males) and 57 mg/kg/day (females) in a mink study (Bucci et al. 1997). In the Bucci et al. (1997) mink study, the next highest level, 262 or 330 mg/kg/day in males and females, respectively, produced hematological changes that included increased Heinz body counts, reticulocytes, mean cell volume, and decreased RBC counts. 

Benjamin, S. A., Hahn, F. F. and Jones, R. K. (1972b). Hematologic changes in dogs with radiation-induced hemangiosarcomas, page 226 in Fission Product Inhalation Program Annual Report 1971-1972, Report No. LF-45 (Lovelace Foundation, Albuquerque, New Mexico). 

Key study Peterson and Bhattacharyya (1985). NOAEL of 5 ppm based upon absence of hematologic changes in mice following 1-h exposure. At 15 ppm, hematologic changes were significant, and at 26 ppm there was 100% mortality. 

Hematological Effects. Hematological effects have not been reported in humans after exposure to -hexane. Some minor hematological changes were seen in rats exposed via inhalation to M-hexane for... 

TABLE 7.5. Some Probable Conditions Affecting Hematological Changes... 

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