Hemoglobin concentration

Two additional parameters, the mean cellular hemoglobin concentration (MCHC) and the mean cellular hemoglobin (MCH), can be obtained. 

Fig. 3. Schematic diagram of a dark field system for measuriag the light scatteriag by a spherical red blood cell where V = volume of sample and HC = hemoglobin concentration. Optical flow cell system having double-angular interval detection at angles 9 and 02.

In principle, the two-angle interval method can produce all CBC parameters within a single measurement channel, uniquely providing ceU-by-ceU hemoglobin concentration. The mean of the concentrations provides an alternative (and direct) measurement of MCHC. The method also provides an alternative HGB measurement, because HGB may be set equal to (RBC x MCV x MCHC)/1000. This method, like the basic light-scattering method, uses the same flow cell to measure platelets and ted cells with the result that the method is capable of providing the CBC parameters RBC, HGB, HCT, MCV, MCHC, MCH, and PLT. The method can also count a sample s white blood cells if the sample s red blood cells have been lysed. 

Hematological Methods. Hematological analyses can Include the determination of the total hemoglobin concentration (In g%), the packed cell volume (PCV In %), the red blood cell count (In 10 /mm ) and reticulocytes count (In %), calculation of the red cell Indices, examination of a blood film, tests to demonstrate the presence of Inclusion bodies and of sickle cells, tests to evaluate the distribution of fetal hemoglobin (Hb-F) Inside the red cells, the red cell osmotic fragility, the concentration of serum Iron (SI), total Iron binding capacity (TIBC), and the survival time of the red cells. Details of all... 

A total hemoglobin concentration of 0 6 to 0 8 mg/ml Is required Table III presents characteristic spectral maxima observed for the known methemoglobln variants Some methemoglobln variants vary In the rate of reaction with KCN ... 

Routine hematological Investigation showed a hemoglobin concentration of 15.6 g/100 ml, a packed red cell volume of 45%, normal erythrocyte morphology, and no Indication of excessive hemolysis. The same abnormal hemoglobin was found In one son. 

Ribavirin causes a dose-related hemolytic anemia. Once treatment has been initiated, the hemoglobin concentration may... 

After treatment, patients should be monitored for symptom resolution, hemoglobin concentration, and adverse effects. 

Mean cell hemoglobin concentration (MCHC) Iron Studies Serum iron 33.4-35.5 g/dL (334-355 g/L) Hemoglobin divided by the hematocrit also low in iron-deficiency anemia. 

After treatment, patients should be monitored for symptom and laboratory value resolution, hemoglobin concentration, and adverse effects. The goal of anemia therapy is to correct the underlying source of the anemia, normalize the hemoglobin, and alleviate associated symptoms. 

Several methods of transfusion maybe used, including simple transfusion, exchange transfusion, or erythrocytapheresis. The goal of chronic transfusion therapy is to maintain the HbS level at less than 30% (0.30) of total hemoglobin concentration. Transfusions usually are administered every 3 to 4 weeks depending on the HbS concentration. For secondary stroke prevention, current studies have indicated that lifelong transfusion may be required, with an increased incidence of recurrence once transfusions are stopped.6... 

Platelet transfusions are used to prevent hemorrhage. Patients with uncomplicated thrombocytopenia can be transfused when the platelet count falls below 10,000/pL (10 x 109/L). Patients who are either highly febrile or actively bleeding may require transfusions at higher levels. Red blood cell transfusions generally are not necessary for a hemoglobin concentration greater than 8 g/dL (80 g/L, 4.96 mmol/L). 

MCHC Mean corpuscular hemoglobin concentration OD Right eye (oculus dexter)... 

Gd gestational day (Gl) = gastric intubation (GO) = gavage in oil Hemato - hematological incr. = increased IPTPP = isopropyl triphenyl phosphate LD = lethal dose, 50% kill LOAEL = lowest-observed-adverse-effect level M = male MCV = mean corpuscular volume MCHC = mean corpuscular hemoglobin concentration mo = month(s) Musc/skel = musculoskeletal NOAEL = no-observed-adverse-effect level NS = not specified NTE = neurotoxic esterase RBC red blood cell Resp = respiratory TBEP = tributoxyethyl phosphate TBP = tributyl phosphate TMP = trimethyl phosphate TNBP = tri-n-butyl phosphate TOP = trioctyl phosphate wk = week(s) x = times yr = year(s). 

G) reductions, - 10%, in hemoglobin and mean cell hemoglobin concentration anemia) ... 

A marked interference with heme synthesis results in a reduction of the hemoglobin concentration in blood. Decreased hemoglobin production, coupled with an increase in erythrocyte destruction, results in a hypochromic, normocytic anemia with associated reticulocytosis. Decreased hemoglobin and anemia have been observed in lead workers and in children with prolonged exposure at higher PbB levels than those noted as threshold levels for inhibition or stimulation of enzyme activities involved in heme synthesis (EPA 1986a). 

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